Aaron J Huebner
Overview
Explore the profile of Aaron J Huebner including associated specialties, affiliations and a list of published articles.
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18
Citations
751
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Recent Articles
1.
Hoetker M, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong L, et al.
Nat Cell Biol
. 2023 Jul;
25(8):1121-1134.
PMID: 37460697
The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a crucial role for H3K36 methylation in the maintenance of cell identities...
2.
Huebner A, Gorelov R, Deviatiiarov R, Demharter S, Kull T, Walsh R, et al.
Nat Cell Biol
. 2023 Jan;
25(3):390-403.
PMID: 36717627
The glandular stomach is composed of two regenerative compartments termed corpus and antrum, and our understanding of the transcriptional networks that maintain these tissues is incomplete. Here we show that...
3.
Singh H, Seruggia D, Madha S, Saxena M, Nagaraja A, Wu Z, et al.
Genes Dev
. 2021 Dec;
36(1-2):38-52.
PMID: 34969824
Barrett's esophagus (BE) and gastric intestinal metaplasia are related premalignant conditions in which areas of human stomach epithelium express mixed gastric and intestinal features. Intestinal transcription factors (TFs) are expressed...
4.
Yagi M, Ji F, Charlton J, Cristea S, Messemer K, Horwitz N, et al.
Genes Dev
. 2021 Aug;
35(17-18):1209-1228.
PMID: 34413137
The generation of myotubes from fibroblasts upon forced MyoD expression is a classic example of transcription factor-induced reprogramming. We recently discovered that additional modulation of signaling pathways with small molecules...
5.
Brumbaugh J, Kim I, Ji F, Huebner A, Di Stefano B, Schwarz B, et al.
Nat Cell Biol
. 2019 Oct;
21(11):1449-1461.
PMID: 31659274
Development and differentiation are associated with profound changes to histone modifications, yet their in vivo function remains incompletely understood. Here, we generated mouse models expressing inducible histone H3 lysine-to-methionine (K-to-M)...
6.
Di Stefano B, Luo E, Haggerty C, Aigner S, Charlton J, Brumbaugh J, et al.
Cell Stem Cell
. 2019 Oct;
25(5):622-638.e13.
PMID: 31588046
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored. Here, we show that suppression of the RNA...
7.
Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner A, Sahakyan A, et al.
Nat Methods
. 2018 Aug;
15(9):732-740.
PMID: 30127506
Human embryonic stem cells (hESCs) can be captured in a primed state in which they resemble the postimplantation epiblast, or in a naive state where they resemble the preimplantation epiblast....
8.
Du P, Pirouz M, Choi J, Huebner A, Clement K, Meissner A, et al.
Cell Stem Cell
. 2018 May;
22(6):851-864.e5.
PMID: 29804889
The embryonic stem cell (ESC) transition from naive to primed pluripotency is marked by major changes in cellular properties and developmental potential. ISY1 regulates microRNA (miRNA) biogenesis, yet its role...
9.
Bar-Nur O, Gerli M, Di Stefano B, Almada A, Galvin A, Coffey A, et al.
Stem Cell Reports
. 2018 May;
10(5):1505-1521.
PMID: 29742392
Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative progenitors termed myoblasts, which play pivotal roles during muscle regeneration. However, current technology does not allow permanent capture of...
10.
Choi J, Huebner A, Clement K, Walsh R, Savol A, Lin K, et al.
Nature
. 2017 Jul;
548(7666):219-223.
PMID: 28746311
Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small molecule inhibitors (2i) in the presence of leukaemia inhibitory factor (LIF) (hereafter termed 2i/L) induces a...