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Brunella Brunelli

Explore the profile of Brunella Brunelli including associated specialties, affiliations and a list of published articles. Areas
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Articles 33
Citations 1447
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Recent Articles
1.
Oldrini D, Di Benedetto R, Carducci M, De Simone D, Massai L, Alfini R, et al.
Vaccines (Basel) . 2023 Dec; 11(12). PMID: 38140177
Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory....
2.
Piccioli D, Buricchi F, Bacconi M, Bechi N, Galli B, Ferlicca F, et al.
Vaccines (Basel) . 2023 Jul; 11(7). PMID: 37515035
Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA have been observed to induce a...
3.
Alfini R, Brunelli B, Bartolini E, Carducci M, Luzzi E, Ferlicca F, et al.
Vaccines (Basel) . 2022 Jul; 10(8). PMID: 35893831
GMMA are outer membrane vesicles (OMVs) released from Gram-negative bacteria genetically modified to enhance OMVs formation that have been shown to be optimal systems to enhance immunogenicity of protein antigens....
4.
Micoli F, Alfini R, Di Benedetto R, Necchi F, Schiavo F, Mancini F, et al.
Front Immunol . 2021 Oct; 12:719315. PMID: 34594333
Nanoparticle systems are being explored for the display of carbohydrate antigens, characterized by multimeric presentation of glycan epitopes and special chemico-physical properties of nano-sized particles. Among them, outer membrane vesicles...
5.
Biolchi A, Tomei S, Brunelli B, Giuliani M, Bambini S, Borrow R, et al.
Infect Dis Ther . 2020 Nov; 10(1):307-316. PMID: 33185849
Introduction: Invasive meningococcal disease (IMD) is an important public health concern. In developed countries, most IMD is caused by meningococcal serogroup B (MenB) and two protein-based MenB vaccines are currently...
6.
Biolchi A, De Angelis G, Moschioni M, Tomei S, Brunelli B, Giuliani M, et al.
Vaccine . 2020 Oct; 38(47):7542-7550. PMID: 33036804
Background: The multicomponent meningococcal serogroup B vaccine (4CMenB) is currently indicated for active immunization against invasive meningococcal disease caused by Neisseria meningitidis serogroup B (MenB). However, genes encoding the 4CMenB...
7.
Micoli F, Alfini R, Di Benedetto R, Necchi F, Schiavo F, Mancini F, et al.
Vaccines (Basel) . 2020 Sep; 8(3). PMID: 32957610
Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are still a threat for human populations, especially in low-...
8.
Natali E, Principato S, Ferlicca F, Bianchi F, Fontana L, Faleri A, et al.
FASEB J . 2020 Jul; 34(8):10329-10341. PMID: 32725956
The classical complement pathway is triggered when antigen-bound immunoglobulins bind to C1q through their Fc region. While C1q binds to a single Fc with low affinity, a higher avidity stable...
9.
Colaprico A, Senesi S, Ferlicca F, Brunelli B, Ugozzoli M, Pallaoro M, et al.
Vaccine . 2020 Feb; 38(19):3600-3609. PMID: 32063436
Aluminum based adjuvants are widely used in commercial vaccines, since they are known to be safe and effective with a variety of antigens. The effect of antigen adsorption onto Aluminum...
10.
Boccadifuoco G, Brunelli B, Mori E, Agnusdei M, Gianfaldoni C, Giuliani M
Methods Mol Biol . 2019 Mar; 1969:205-215. PMID: 30877679
Meningococcal Antigen Typing System (MATS) is the combination of a sandwich ELISA (Enzyme Linked Immunosorbent Assay) developed to estimate the level of expression and immunoreactivity of the antigen components (fHbp,...