Bruce R Conklin
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Explore the profile of Bruce R Conklin including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
9372
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Recent Articles
11.
Pantazis C, Yang A, Lara E, McDonough J, Blauwendraat C, Peng L, et al.
Cell Stem Cell
. 2022 Dec;
29(12):1685-1702.e22.
PMID: 36459969
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings...
12.
Iwagawa T, Masumoto H, Tabuchi H, Tani K, Conklin B, Watanabe S
J Gene Med
. 2022 Nov;
25(2):e3464.
PMID: 36413603
Background: Exon-skipping is a powerful genetic tool, especially when delivering genes using an AAV-mediated full-length gene supplementation strategy is difficult owing to large length of genes. Here, we used engineered...
13.
Zhu L, Choudhary K, Gonzalez-Teran B, Ang Y, Thomas R, Stone N, et al.
Circulation
. 2022 Aug;
146(10):770-787.
PMID: 35938400
Background: GATA4 (GATA-binding protein 4), a zinc finger-containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been...
14.
Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Huttenhain R, et al.
Cell
. 2022 Feb;
185(5):794-814.e30.
PMID: 35182466
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein...
15.
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Samelson A, Tran Q, Robinot R, Carrau L, Rezelj V, Mac Kain A, et al.
Nat Cell Biol
. 2022 Jan;
24(1):24-34.
PMID: 35027731
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways...
16.
Fenix A, Miyaoka Y, Bertero A, Blue S, Spindler M, Tan K, et al.
Nat Commun
. 2021 Nov;
12(1):6324.
PMID: 34732726
Mutations in the cardiac splicing factor RBM20 lead to malignant dilated cardiomyopathy (DCM). To understand the mechanism of RBM20-associated DCM, we engineered isogenic iPSCs with DCM-associated missense mutations in RBM20...
17.
Feliciano C, Wu K, Watry H, Marley C, Ramadoss G, Ghanim H, et al.
Front Cell Dev Biol
. 2021 Sep;
9:723023.
PMID: 34485306
Many neuromuscular disorders are caused by dominant missense mutations that lead to dominant-negative or gain-of-function pathology. This category of disease is challenging to address via drug treatment or gene augmentation...
18.
Vila O, Chavez M, Ma S, Yeager K, Zholudeva L, Colon-Mercado J, et al.
Biomaterials
. 2021 Aug;
276:121033.
PMID: 34403849
Functional human tissues engineered from patient-specific induced pluripotent stem cells (hiPSCs) hold great promise for investigating the progression, mechanisms, and treatment of musculoskeletal diseases in a controlled and systematic manner....
19.
Dewell T, Gjoni K, Liu A, Libby A, Moore A, So P, et al.
Stem Cell Res
. 2021 Jun;
53:102368.
PMID: 34087997
Age-related macular degeneration and genetic forms of blindness such as Best Disease and Retinitis Pigmentosa can be caused by degeneration of the Retinal Pigment Epithelium (RPE). RPE generated from patient-derived...
20.
Perez-Bermejo J, Kang S, Rockwood S, Simoneau C, Joy D, Silva A, et al.
Sci Transl Med
. 2021 Mar;
13(590).
PMID: 33723017
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell (iPSC)-derived heart cells to severe...