Bruce P Damiano
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Explore the profile of Bruce P Damiano including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
284
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Recent Articles
1.
Lu H, Damiano B, Kreir M, Rohrbacher J, van der Linde H, Saidov T, et al.
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759755
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. We evaluated...
2.
Damiano B, van der Linde H, Van Deuren B, Somers Y, Lubomirski M, Teisman A, et al.
J Pharmacol Toxicol Methods
. 2014 Dec;
72:72-84.
PMID: 25450838
Introduction: Preclinical proarrhythmic risk assessment of drug candidates is focused predominantly on arrhythmias arising from repolarization abnormalities. However, drug-induced cardiac conduction slowing is associated with significant risk of life-threatening ventricular...
3.
Connelly M, DAndrea M, Qi J, Dzordzorme K, Damiano B
J Histochem Cytochem
. 2012 Jun;
60(9):694-705.
PMID: 22740344
Endothelial lipase (EL), a member of the triglyceride lipase gene family, has been shown to be a key player in HDL metabolism. Northern blots revealed that EL was highly expressed...
4.
Sarich T, Connelly M, Schranz D, Ghosh A, Manitpisitkul P, Leary E, et al.
Int J Clin Pharmacol Ther
. 2012 May;
50(8):584-94.
PMID: 22578199
Objective: To assess and validate the application of a non-radioactive assay for cholesteryl ester transfer protein (CETP) activity in clinical samples. Design And Methods: In this Phase 0 study, CETP...
5.
Parry T, Huang Z, Chen C, Connelly M, Perzborn E, Andrade-Gordon P, et al.
Blood Coagul Fibrinolysis
. 2011 Oct;
22(8):720-6.
PMID: 21986468
Rivaroxaban, an oral, direct factor Xa inhibitor, has been approved in several countries for thromboprophylaxis after elective hip or knee arthroplasty based on favorable benefit-risk profile and improved efficacy compared...
6.
Parks D, Parsons W, Colburn R, Meegalla S, Ballentine S, Illig C, et al.
J Med Chem
. 2010 Dec;
54(1):233-47.
PMID: 21128593
Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel that is thermoresponsive to cool to cold temperatures (8-28 °C) and also may be activated by chemical agonists such...
7.
Darrow A, Olson M, Xin H, Burke S, Smith C, Schalk-Hihi C, et al.
J Lipid Res
. 2010 Nov;
52(2):374-82.
PMID: 21062953
Endothelial lipase (EL) is a phospholipase A1 (PLA1) enzyme that hydrolyzes phospholipids at the sn-1 position to produce lysophospholipids and free fatty acids. Measurement of the PLA1 activity of EL...
8.
Lu T, Markotan T, Ballentine S, Giardino E, Spurlino J, Crysler C, et al.
J Med Chem
. 2010 Jan;
53(4):1843-56.
PMID: 20102150
We have identified RWJ-671818 (8) as a novel, low molecular weight, orally active inhibitor of human alpha-thrombin (K(i) = 1.3 nM) that is potentially useful for the acute and chronic...
9.
Connelly M, Parry T, Giardino E, Huang Z, Cheung W, Chen C, et al.
J Cardiovasc Pharmacol
. 2010 Jan;
55(5):459-68.
PMID: 20051879
Objective: Torcetrapib, a prototype cholesteryl ester transfer protein (CETP) inhibitor with potential for decreasing atherosclerotic disease, increased cardiovascular events in clinical trials. The identified hypertensive and aldosterone-elevating actions of torcetrapib...
10.
Giardino E, Haertlein B, de Garavilla L, Costanzo M, Damiano B, Andrade-Gordon P, et al.
Blood Coagul Fibrinolysis
. 2009 Dec;
21(2):128-34.
PMID: 20010091
Whereas heparin functions as an antithrombotic agent by promoting antithrombin III-based inhibition of thrombin and factor Xa, there is less appreciation for the combination behavior with small-molecule, direct inhibitors of...