Bruce A Bunnell
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Explore the profile of Bruce A Bunnell including associated specialties, affiliations and a list of published articles.
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200
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6792
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Recent Articles
1.
Gao Q, Zhang X, Makarcyzk M, Wong L, Quig M, Shinohara I, et al.
Osteoarthritis Cartilage
. 2025 Feb;
PMID: 39978574
Objective: To investigate the interaction among the cells thought to be foundational to inflammation, fibrosis, and angiogenesis in the synovial membrane. Method: We encapsulated fibroblasts, polarized macrophages, and endothelial cells...
2.
Gao Q, Teissier V, Zhu W, Makarcyzk M, Shinohara I, Murayama M, et al.
Res Sq
. 2024 Dec;
PMID: 39711538
Patient-specific induced pluripotent stem cells (iPSCs)-based modeling potentially recapitulates the pathology and mechanisms more faithfully than cell line models and general animal models. Utilizing iPSC-derived cells for personalized bone formation...
3.
Rinderle C, Baker C, Lagarde C, Nguyen K, Al-Ghadban S, Matossian M, et al.
Anticancer Drugs
. 2024 Dec;
36(1):39-48.
PMID: 39671264
Triple-negative breast cancer (TNBC) is a highly invasive breast cancer subtype that is challenging to treat due to inherent heterogeneity and absence of estrogen, progesterone, and human epidermal growth factor...
4.
Cekuc M, Ergul Y, Pius A, Meagan M, Shinohara I, Murayama M, et al.
J Inflamm Res
. 2024 Dec;
17:10383-10396.
PMID: 39654863
Background: Corticosteroids provide well-established therapeutic benefits; however, they are also accompanied by adverse effects on bone. Metformin is a widely used medication for managing type 2 diabetes mellitus. Recent studies...
5.
Lagarde C, Thapa K, Cullen N, Hawes M, Salim K, Benz M, et al.
Front Endocrinol (Lausanne)
. 2024 Oct;
15:1465727.
PMID: 39439572
At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with...
6.
Mechanical Disruption by Focused Ultrasound Re-sensitizes ER+ Breast Cancer Cells to Hormone Therapy
Murad H, Sabol R, Nyiramana J, Twizeyimana A, Bortz E, Matossian M, et al.
Ultrasound Med Biol
. 2024 Sep;
50(12):1885-1892.
PMID: 39277462
Objective: Tamoxifen is the most used agent to treat estrogen receptor-positive (ER+) breast cancer (BC). While it decreases the risk of cancer recurrence by 50%, many patients develop resistance to...
7.
Bashore F, Min S, Chen X, Howell S, Rinderle C, Morel G, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1325-1333.
PMID: 39140040
Acylaminoindazole-based inhibitors of CDKL2 were identified via analyses of cell-free binding and selectivity data. Compound was selected as a CDKL2 chemical probe based on its potent inhibition of CDKL2 enzymatic...
8.
Carney E, Ghasem Zadeh Moslabeh F, Kang S, Bunnell B, Lee M, Habibi N
Heliyon
. 2024 Jul;
10(13):e33629.
PMID: 39071664
Enzyme-induced self-assembly (EISA) is a recently developed nanotechnology technique in which small molecules are induced by cellular enzymes self-assembling into nanostructures inside cancer cells. This technique can boost the efficacy...
9.
Kapic A, Sabnis N, Dossou A, Chavez J, Ceresa L, Gryczynski Z, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000485
Cytotoxic activity has been reported for the xanthone α-mangostin (AMN) against Glioblastoma multiforme (GBM), an aggressive malignant brain cancer with a poor prognosis. Recognizing that AMN's high degree of hydrophobicity...
10.
Bashore F, Min S, Chen X, Howell S, Rinderle C, Morel G, et al.
bioRxiv
. 2024 May;
PMID: 38798634
Acylaminoindazole-based inhibitors of CDKL2 were identified via analyses of cell-free binding and selectivity data. Compound was selected as a CDKL2 chemical probe based on its potent inhibition of CDKL2 enzymatic...