Brooke E Christian
Overview
Explore the profile of Brooke E Christian including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
436
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Esterly H, Crilly C, Piszkiewicz S, Shovlin D, Pielak G, Christian B
Front Pharmacol
. 2020 Oct;
11:565969.
PMID: 33117164
Tardigrades are microscopic animals well-known for their stress tolerance, including the ability to survive desiccation. This survival requires cytosolic abundant heat soluble (CAHS) proteins. CAHS D protects enzymes from desiccation-...
2.
Cox C, McKay S, Holmbeck M, Christian B, Scortea A, Tsay A, et al.
Cell Metab
. 2018 Aug;
28(5):776-786.e5.
PMID: 30122556
Transient mitochondrial stress can promote beneficial physiological responses and longevity, termed "mitohormesis." To interrogate mitohormetic pathways in mammals, we generated mice in which mitochondrial superoxide dismutase 2 (SOD2) can be...
3.
Zhang Y, Lee J, Paull T, Gehrke S, DAlessandro A, Dou Q, et al.
Sci Signal
. 2018 Jul;
11(538).
PMID: 29991649
Mitochondria are integral to cellular energy metabolism and ATP production and are involved in regulating many cellular processes. Mitochondria produce reactive oxygen species (ROS), which not only can damage cellular...
4.
Camell C, Nguyen K, Jurczak M, Christian B, Shulman G, Shadel G, et al.
J Biol Chem
. 2015 Oct;
290(49):29402-13.
PMID: 26438821
Dietary lipid overload and calorie excess during obesity is a low grade chronic inflammatory state with diminished ability to appropriately metabolize glucose or lipids. Macrophages are critical in maintaining adipose...
5.
Christian B, Shadel G
Curr Biol
. 2014 Mar;
24(5):R206-8.
PMID: 24602889
Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded...
6.
Christian B, Spremulli L
Biochim Biophys Acta
. 2011 Dec;
1819(9-10):1035-54.
PMID: 22172991
Protein synthesis in mammalian mitochondria produces 13 proteins that are essential subunits of the oxidative phosphorylation complexes. This review provides a detailed outline of each phase of mitochondrial translation including...
7.
Woo D, Green P, Santos J, DSouza A, Walther Z, Martin W, et al.
Am J Pathol
. 2011 Nov;
180(1):24-31.
PMID: 22056359
Alterations in mitochondrial oxidative phosphorylation have long been documented in tumors. Other types of mitochondrial dysfunction, including altered reactive oxygen species (ROS) production and apoptosis, also can contribute to tumorigenesis...
8.
Engelhard J, Christian B, Weingarten L, Kuntz G, Spremulli L, Dick T
Free Radic Biol Med
. 2011 Feb;
50(10):1234-41.
PMID: 21295137
Reactive oxygen species (ROS) are released at the mitochondrial inner membrane by the electron transport chain (ETC). Increasing evidence suggests that mitochondrial H2O2 acts as a signaling molecule and participates...
9.
Christian B, Spremulli L
J Biol Chem
. 2010 Jul;
285(36):28379-86.
PMID: 20610392
Mammalian mitochondrial mRNAs are basically leaderless, having few or no untranslated nucleotides prior to the 5'-start codon. We demonstrate here that mammalian mitochondrial 55 S ribosomes preferentially form initiation complexes...
10.
Akama K, Christian B, Jones C, Ueda T, Takeuchi N, Spremulli L
Biochim Biophys Acta
. 2010 May;
1802(7-8):692-8.
PMID: 20435138
Mammalian mitochondria synthesize a set of thirteen proteins that are essential for energy generation via oxidative phosphorylation. The genes for all of the factors required for synthesis of the mitochondrially...