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Brian W Brannigan

Explore the profile of Brian W Brannigan including associated specialties, affiliations and a list of published articles. Areas
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Articles 23
Citations 8139
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Recent Articles
1.
Bersani F, Lee E, Kharchenko P, Xu A, Liu M, Xega K, et al.
Proc Natl Acad Sci U S A . 2015 Nov; 112(49):15148-53. PMID: 26575630
Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that...
2.
Miyamoto D, Zheng Y, Wittner B, Lee R, Zhu H, Broderick K, et al.
Science . 2015 Sep; 349(6254):1351-6. PMID: 26383955
Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone metastases is challenging; hence, sampling circulating...
3.
Kim W, Wittner B, Amzallag A, Brannigan B, Ting D, Ramaswamy S, et al.
J Biol Chem . 2015 Apr; 290(23):14381-90. PMID: 25882849
WTX encodes a tumor suppressor implicated in the pediatric kidney cancer Wilms tumor and in mesenchymal differentiation with potentially distinct functions in the cytoplasm, at the plasma membrane, and in...
4.
Ting D, Wittner B, Ligorio M, Vincent Jordan N, Shah A, Miyamoto D, et al.
Cell Rep . 2014 Sep; 8(6):1905-1918. PMID: 25242334
Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define their composition, we compared genome-wide expression profiles...
5.
Aceto N, Bardia A, Miyamoto D, Donaldson M, Wittner B, Spencer J, et al.
Cell . 2014 Aug; 158(5):1110-1122. PMID: 25171411
Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with tagged mammary...
6.
Luo X, Mitra D, Sullivan R, Wittner B, Kimura A, Pan S, et al.
Cell Rep . 2014 Apr; 7(3):645-53. PMID: 24746818
Melanoma is an invasive malignancy with a high frequency of blood-borne metastases, but circulating tumor cells (CTCs) have not been readily isolated. We adapted microfluidic CTC capture to a tamoxifen-driven...
7.
Miyamoto D, Lee R, Stott S, Ting D, Wittner B, Ulman M, et al.
Cancer Discov . 2012 Oct; 2(11):995-1003. PMID: 23093251
Unlabelled: Androgen deprivation therapy (ADT) is initially effective in treating metastatic prostate cancer, and secondary hormonal therapies are being tested to suppress androgen receptor (AR) reactivation in castration-resistant prostate cancer...
8.
Yu M, Ting D, Stott S, Wittner B, Ozsolak F, Paul S, et al.
Nature . 2012 Jul; 487(7408):510-3. PMID: 22763454
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. Although these cells are extraordinarily rare, they may identify cellular pathways contributing to...
9.
Ting D, Lipson D, Paul S, Brannigan B, Akhavanfard S, Coffman E, et al.
Science . 2011 Jan; 331(6017):593-6. PMID: 21233348
Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these...
10.
Ozsolak F, Ting D, Wittner B, Brannigan B, Paul S, Bardeesy N, et al.
Nat Methods . 2010 Jul; 7(8):619-21. PMID: 20639869
Generating reliable expression profiles from minute cell quantities is critical for scientific discovery and potential clinical applications. Here we present low-quantity digital gene expression (LQ-DGE), an amplification-free approach involving capture...