Brian P H Metzger
Overview
Explore the profile of Brian P H Metzger including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
369
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Recent Articles
11.
Maclean C, Metzger B, Yang J, Ho W, Moyers B, Zhang J
Mol Biol Evol
. 2017 May;
34(10):2486-2502.
PMID: 28472365
The budding yeast Saccharomyces cerevisiae is the best studied eukaryote in molecular and cell biology, but its utility for understanding the genetic basis of phenotypic variation in natural populations is...
12.
Metzger B, Wittkopp P, Coolon J
Genome Biol Evol
. 2017 Mar;
9(4):843-854.
PMID: 28338820
Heritable changes in gene expression are important contributors to phenotypic differences within and between species and are caused by mutations in cis-regulatory elements and trans-regulatory factors. Although previous work has...
13.
Contrasting Frequencies and Effects of cis- and trans-Regulatory Mutations Affecting Gene Expression
Metzger B, Duveau F, Yuan D, Tryban S, Yang B, Wittkopp P
Mol Biol Evol
. 2016 Jan;
33(5):1131-46.
PMID: 26782996
Heritable differences in gene expression are caused by mutations in DNA sequences encoding cis-regulatory elements and trans-regulatory factors. These two classes of regulatory change differ in their relative contributions to...
14.
Metzger B, Yuan D, Gruber J, Duveau F, Wittkopp P
Nature
. 2015 Mar;
521(7552):344-7.
PMID: 25778704
Genetic variation segregating within a species reflects the combined activities of mutation, selection, and genetic drift. In the absence of selection, polymorphisms are expected to be a random subset of...
15.
Duveau F, Metzger B, Gruber J, Mack K, Sood N, Brooks T, et al.
G3 (Bethesda)
. 2014 May;
4(7):1205-16.
PMID: 24789747
Genetic variants identified by mapping are biased toward large phenotypic effects because of methodologic challenges for detecting genetic variants with small phenotypic effects. Recently, bulk segregant analysis combined with next-generation...