Brian N Dominy
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Explore the profile of Brian N Dominy including associated specialties, affiliations and a list of published articles.
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23
Citations
275
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Recent Articles
1.
Milanes J, Yan V, Pham C, Muller F, Kwain S, Rees K, et al.
PLoS Pathog
. 2024 Aug;
20(8):e1012412.
PMID: 39088549
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality...
2.
Miller B, Narangoda C, Kwain S, Bridges W, Noori M, Solomon E, et al.
J Org Chem
. 2024 Mar;
89(7):4990-4999.
PMID: 38494854
Previously, we described the synthesis of stable, bicyclic examples of the rather rare diazacyclobutene (DCB) motif by means of a cycloaddition between triazolinediones and electron-rich thiolated alkynes. Here, we report...
3.
Milanes J, Yan V, Pham C, Muller F, Kwain S, Rees K, et al.
bioRxiv
. 2024 Jan;
PMID: 38293107
Infections with the pathogenic free-living amoebae can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains...
4.
Glucose metabolism in the pathogenic free-living amoebae: Tempting targets for treatment development
Milanes J, Kwain S, Drawdy A, Dodson L, Monaghan M, Rice C, et al.
Chem Biol Drug Des
. 2023 Oct;
103(1):e14377.
PMID: 37864277
Pathogenic free-living amoebae (pFLA) are single-celled eukaryotes responsible for causing intractable infections with high morbidity and mortality in humans and animals. Current therapeutic approaches include cocktails of antibiotic, antifungal, and...
5.
Thornton L, Key M, Micchelli C, Stasic A, Kwain S, Floyd K, et al.
mBio
. 2023 Jun;
14(4):e0017423.
PMID: 37326431
Microbial pathogens use proteases for their infections, such as digestion of proteins for nutrients and activation of their virulence factors. As an obligate intracellular parasite, must invade host cells to...
6.
Kwain S, Dominy B, Whitehead K, Miller B, Whitehead D
Chem Biol Drug Des
. 2023 Apr;
102(3):486-499.
PMID: 37062591
The α-amylase, SusG, is a principal component of the Bacteroides thetaiotaomicron (Bt) starch utilization system (Sus) used to metabolize complex starch molecules in the human gastrointestinal (GI) tract. We previously...
7.
Thornton L, Key M, Micchelli C, Stasic A, Kwain S, Floyd K, et al.
bioRxiv
. 2023 Jan;
PMID: 36712013
Importance: is a microbial pathogen that is well adapted for disseminating infections. It can infect virtually all warm-blooded animals. Approximately one-third of the human population carries toxoplasmosis. During infection, the...
8.
Xia B, Liu Y, Guevara J, Li J, Jilich C, Yang Y, et al.
Sci Rep
. 2017 Apr;
7:45978.
PMID: 28397787
Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the removal of uracil. Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and single-stranded...
9.
Lee D, Liu Y, Lee H, Xia B, Brice A, Park S, et al.
Nucleic Acids Res
. 2015 Jan;
43(2):1081-9.
PMID: 25550433
The uracil DNA glycosylase superfamily consists of several distinct families. Family 2 mismatch-specific uracil DNA glycosylase (MUG) from Escherichia coli is known to exhibit glycosylase activity on three mismatched base...
10.
Xia B, Liu Y, Li W, Brice A, Dominy B, Cao W
J Biol Chem
. 2014 May;
289(26):18413-26.
PMID: 24838246
UDGb belongs to family 5 of the uracil DNA glycosylase (UDG) superfamily. Here, we report that family 5 UDGb from Thermus thermophilus HB8 is not only a uracil DNA glycosyase...