Brian M Shewchuk
Overview
Explore the profile of Brian M Shewchuk including associated specialties, affiliations and a list of published articles.
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16
Citations
194
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Recent Articles
1.
Patel B, Yao F, Howenstine A, Takenaka R, Hyatt J, Sears K, et al.
J Mol Biol
. 2020 Oct;
432(23):6127-6145.
PMID: 33058877
Mitochondrial fatty acid oxidation (FAO) contributes to the proton motive force that drives ATP synthesis in many mammalian tissues. In eutherian (placental) mammals, brown adipose tissue (BAT) can also dissipate...
2.
Shaikh S, Shaver P, Shewchuk B
Mol Nutr Food Res
. 2018 May;
62(13):e1800219.
PMID: 29738112
Scope: Dietary fat composition can modulate gene expression in peripheral tissues in obesity. Observations of the dysregulation of growth hormone (GH) in obesity indicate that these effects extend to the...
3.
Wang L, DeMarco S, Peaks M, Maiorana-Boutilier A, Chen J, Crouch M, et al.
Exp Dermatol
. 2017 Apr;
26(11):1004-1011.
PMID: 28370539
Retinoids, natural and synthetic derivatives of vitamin A, induce cellular changes by activating nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR). Although the ability of retinoids to govern...
4.
Holt A, Martin D, Shaver P, Adderley S, Stone J, Joshi C, et al.
Cell Signal
. 2016 Jun;
28(9):1364-1379.
PMID: 27302407
Coronary artery disease (CAD) accounts for over half of all cardiovascular disease-related deaths. Uncontrolled arterial smooth muscle (ASM) cell migration is a major component of CAD pathogenesis and efforts aimed...
5.
Maples J, Brault J, Witczak C, Park S, Hubal M, Weber T, et al.
Am J Physiol Endocrinol Metab
. 2015 Jun;
309(4):E345-56.
PMID: 26058865
The ability to increase fatty acid oxidation (FAO) in response to dietary lipid is impaired in the skeletal muscle of obese individuals, which is associated with a failure to coordinately...
6.
Maples J, Brault J, Shewchuk B, Witczak C, Zou K, Rowland N, et al.
Physiol Genomics
. 2015 Feb;
47(5):139-46.
PMID: 25670728
The skeletal muscle of obese individuals exhibits an impaired ability to increase the expression of genes linked with fatty acid oxidation (FAO) upon lipid exposure. The present study determined if...
7.
Nakonechnaya A, Shewchuk B
Endocr Res
. 2014 Oct;
40(2):97-105.
PMID: 25330355
Purpose: Prostate cancer cells are responsive to multiple hormones and growth factors that can affect cell function. These effects may include modulating cell proliferation and apoptosis, but the ability to...
8.
Shewchuk B
Prostaglandins Leukot Essent Fatty Acids
. 2014 Oct;
91(6):277-87.
PMID: 25287609
The hypothalamic-pituitary (H-P) axis integrates complex physiological and environmental signals and responds to these cues by modulating the synthesis and secretion of multiple pituitary hormones to regulate peripheral tissues. Prostaglandins...
9.
Teague H, Harris M, Fenton J, Lallemand P, Shewchuk B, Shaikh S
J Lipid Res
. 2014 May;
55(7):1420-33.
PMID: 24837990
EPA and DHA are not biologically equivalent; however, their individual activity on B cells is unknown. We previously reported fish oil enhanced murine B-cell activity in obesity. To distinguish between...
10.
Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression
Ho Y, Shewchuk B, Liebhaber S, Cooke N
Mol Cell Biol
. 2013 Feb;
33(9):1723-34.
PMID: 23428872
For many mammalian genes, initiation of transcription during embryonic development must be subsequently sustained over extensive periods of adult life. It remains unclear whether maintenance of gene expression reflects the...