Brian M Shewchuk
Overview
Explore the profile of Brian M Shewchuk including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
194
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0
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Recent Articles
11.
Nakonechnaya A, Jefferson H, Chen X, Shewchuk B
J Cell Biochem
. 2012 Dec;
114(6):1322-35.
PMID: 23238889
The prostate gland is regulated by multiple hormones and growth factors that may also affect prostate tumorigenesis. Growth hormone (GH) contributes to prostate development and function, but the direct effects...
12.
Hunsaker T, Jefferson H, Morrison J, Franklin A, Shewchuk B
J Mol Biol
. 2011 Nov;
415(1):29-45.
PMID: 22094313
The human growth hormone gene (hGH-N) is regulated by a distal locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs). The region encompassing HSI and HSII contains...
13.
Whelan J, Kellogg A, Shewchuk B, Hewan-Lowe K, Bertrand F
J Cell Biochem
. 2009 May;
107(5):992-1001.
PMID: 19479935
Prostate tumorigenesis is associated with loss of PTEN gene expression. We and others have recently reported that PTEN is regulated by Notch-1 signaling. Herein, we tested the hypothesis that alterations...
14.
Hogan K, Jefferson H, Karschner V, Shewchuk B
J Mol Biol
. 2009 May;
390(1):26-44.
PMID: 19427323
The POU domain transcription factor Pit-1 is expressed in somatotropes, lactotropes, and thyrotropes of the anterior pituitary. Pit-1 is essential for the establishment of these lineages during development and regulates...
15.
Shewchuk B, Ho Y, Liebhaber S, Cooke N
Mol Cell Biol
. 2006 Aug;
26(17):6535-46.
PMID: 16914737
Activation of the human growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus control region (LCR). This LCR is composed of DNase I-hypersensitive sites (HS) located -14.5...
16.
Shewchuk B, Liebhaber S, Cooke N
Proc Natl Acad Sci U S A
. 2002 Aug;
99(18):11784-9.
PMID: 12189206
The human GH (hGH) gene cluster is regulated by a remote 5' locus control region (LCR). HSI, an LCR component located 14.5 kb 5' to the hGH-N promoter, constitutes the...