Brian J Wilkinson
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Explore the profile of Brian J Wilkinson including associated specialties, affiliations and a list of published articles.
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69
Citations
1566
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Recent Articles
1.
Raskovic D, Alvarado G, Hines K, Xu L, Gatto C, Wilkinson B, et al.
Biochim Biophys Acta Biomembr
. 2024 Nov;
1867(1):184395.
PMID: 39500386
Staphylococcus aureus readily adapts to various environments and quickly develops antibiotic resistance, which has led to an increase in multidrug-resistant infections. Hence, S. aureus presents a significant global health issue...
2.
Barbarek S, Shah R, Paul S, Alvarado G, Appala K, Phillips C, et al.
J Bacteriol
. 2024 Jul;
206(7):e0018724.
PMID: 38953643
Importance: We show that can use its known ability to incorporate exogenous fatty acids to enhance its growth at low temperatures. Individual species of phosphatidylglycerols and diglycosyldiacylglycerols bearing one or...
3.
Freeman C, Hansen T, Urbauer R, Wilkinson B, Singh V, Hines K
mSphere
. 2024 May;
9(6):e0011524.
PMID: 38752757
Importance: The cationic lipopeptide antimicrobial daptomycin has become an essential tool for combating infections with that display reduced susceptibility to β-lactams or vancomycin. Since daptomycin's activity is based on interaction...
4.
Raskovic D, Alvarado G, Hines K, Xu L, Gatto C, Wilkinson B, et al.
bioRxiv
. 2024 May;
PMID: 38746422
readily adapts to various environments and quickly develops antibiotic resistance, which has led to an increase in multidrug-resistant infections. Hence, presents a significant global health issue and its adaptations to...
5.
Barbarek S, Shah R, Paul S, Alvarado G, Appala K, Henderson E, et al.
bioRxiv
. 2024 Feb;
PMID: 38352554
It is well established that can incorporate exogenous straight-chain unsaturated fatty acids (SCUFAs) into membrane phospho- and glyco-lipids from various sources in supplemented culture media, and when growing in an...
6.
Freeman C, Hansen T, Urbauer R, Wilkinson B, Singh V, Hines K
bioRxiv
. 2023 Apr;
PMID: 37090586
Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant . In the rare event of failed daptomycin therapy, the source of resistance...
7.
Gupta S, Pfeltz R, Wilkinson B, Gustafson J
Antibiotics (Basel)
. 2022 Aug;
11(8).
PMID: 36009920
Physiological experimentation, transcriptomics, and metabolomics were engaged to compare a fusidic acid-resistant mutant SH10001st-2 to its parent strain SH1000. SH10001st-2 harbored a mutation (H457Y) in the gene which encodes the...
8.
Tiwari K, Sen S, Gatto C, Wilkinson B
Methods Mol Biol
. 2021 Jul;
2341:55-68.
PMID: 34264461
Fluorescence polarization is a method to determine membrane fluidity using a hydrophobic fluorescent dye that intercalates into the fatty acid bilayer. A spectrofluorometer is used to polarize UV light as...
9.
Lamichhane-Khadka R, Dulal S, Cuaron J, Pfeltz R, Gupta S, Wilkinson B, et al.
Antibiotics (Basel)
. 2021 Jun;
10(5).
PMID: 34069103
Comparative genomic sequencing of laboratory-derived vancomycin-intermediate (VISA) (MM66-3 and MM66-4) revealed unique mutations in both MM66-3 (in and ), and MM66-4 (in and ), compared to hetero-VISA parent strain MM66....
10.
Freeman C, Hynds H, Carpenter J, Appala K, Bimpeh K, Barbarek S, et al.
J Am Soc Mass Spectrom
. 2021 May;
32(9):2376-2385.
PMID: 34014662
Up to 80% of the fatty acids in membrane lipids are branched, rather than straight-chain, fatty acids. The branched fatty acids (BCFAs) may have either an even or odd number...