Brian J North
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Explore the profile of Brian J North including associated specialties, affiliations and a list of published articles.
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52
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4488
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Recent Articles
1.
Pun R, Thapa A, Takafuji S, Suzuki R, Kay G, Howard T, et al.
J Am Heart Assoc
. 2025 Mar;
:e038286.
PMID: 40055864
Background: Congenital heart defects are structural anomalies present at birth that can affect the function of the heart. Aneuploidy is a significant risk factor for congenital heart defects. Mosaic variegated...
2.
North B, Ohnstad A, Ragusa M, Shoemaker C
J Cell Biol
. 2025 Feb;
224(4).
PMID: 39928048
During autophagy, toxic cargo is encapsulated by autophagosomes and trafficked to lysosomes for degradation. NBR1, an autophagy receptor targeting ubiquitinated aggregates, serves as a model for studying the multivalent, heterotypic...
3.
Pun R, North B
Front Cell Dev Biol
. 2025 Feb;
12:1491394.
PMID: 39911185
The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of sister chromatids between daughter cells during anaphase. This essential regulatory checkpoint prevents aneuploidy which can lead...
4.
Pun R, Kumari N, Monieb R, Wagh S, North B
Semin Cancer Biol
. 2024 Nov;
106-107:201-216.
PMID: 39490401
Aging is a significant risk factor for cancer which is due, in part, to heightened genomic instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring accurate...
5.
Ege T, Tao L, North B
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273652
Aging, a complex process marked by molecular and cellular changes, inevitably influences tissue and organ homeostasis and leads to an increased onset or progression of many chronic diseases and conditions,...
6.
North B, Ohnstad A, Ragusa M, Shoemaker C
bioRxiv
. 2024 May;
PMID: 38766171
During autophagy, potentially toxic cargo is enveloped by a newly formed autophagosome and trafficked to the lysosome for degradation. Ubiquitinated protein aggregates, a key target for autophagy, are identified by...
7.
Pun R, Cavanaugh A, Aldrich E, Tran O, Rudd J, Hansen L, et al.
iScience
. 2024 Feb;
27(3):109033.
PMID: 38375220
Downregulation of intercellular communication through suppression of gap junctional conductance is necessary during wound healing. Connexin 43 (Cx43), a prominent gap junction protein in skin, is downregulated following wounding to...
8.
Zou Q, Liu M, Liu K, Zhang Y, North B, Wang B
Cell Oncol (Dordr)
. 2023 Feb;
46(3):545-570.
PMID: 36745329
Background: Human malignancies are composed of heterogeneous subpopulations of cancer cells with phenotypic and functional diversity. Among them, a unique subset of cancer stem cells (CSCs) has both the capacity...
9.
Pun R, Kim M, North B
Front Cardiovasc Med
. 2023 Jan;
9:1080131.
PMID: 36712244
Intercellular communication mediated by gap junction channels and hemichannels composed of Connexin 43 (Cx43) is vital for the propagation of electrical impulses through cardiomyocytes. The carboxyl terminal tail of Cx43...
10.
Dai X, Zhang J, North B, Guo J
Front Immunol
. 2022 Aug;
13:1006145.
PMID: 36032068
No abstract available.