Brian J North
Overview
Explore the profile of Brian J North including associated specialties, affiliations and a list of published articles.
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52
Citations
4488
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Recent Articles
11.
Liu J, Tokheim C, Lee J, Gan W, North B, Liu X, et al.
Nat Commun
. 2021 Nov;
12(1):6704.
PMID: 34795215
Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and progression. Our study proposes a model whereby oncogenic gene...
12.
Shimizu K, Gi M, Suzuki S, North B, Watahiki A, Fukumoto S, et al.
Cell Rep
. 2021 Nov;
37(6):109988.
PMID: 34758305
The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the pro-survival BCL2 family and is frequently amplified or elevated in human cancers. MCL1 is highly unstable, with its stability...
13.
Ma Y, North B, Shu J
Mol Biol Rep
. 2021 Sep;
48(9):6589-6601.
PMID: 34476738
DNA topoisomerases II (TOP2) are peculiar enzymes (TOP2α and TOP2β) that modulate the conformation of DNA by momentarily breaking double-stranded DNA to allow another strand to pass through, and then...
14.
Bloom C, North B
Cell Biosci
. 2021 Apr;
11(1):76.
PMID: 33892776
BubR1 is an essential component of the spindle assembly checkpoint (SAC) during mitosis where it functions to prevent anaphase onset to ensure proper chromosome alignment and kinetochore-microtubule attachment. Loss or...
15.
Kumari N, Reabroi S, North B
Mediators Inflamm
. 2021 Mar;
2021:6655417.
PMID: 33746610
G protein-coupled receptors (GPCRs) represent a large family of transmembrane proteins that transduce an external stimulus into a variety of cellular responses. They play a critical role in various pathological...
16.
Ohnstad A, Delgado J, North B, Nasa I, Kettenbach A, Schultz S, et al.
EMBO J
. 2020 Nov;
39(24):e104948.
PMID: 33226137
Autophagosome formation requires multiple autophagy-related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including...
17.
Gao Y, Nihira N, Bu X, Chu C, Zhang J, Kolodziejczyk A, et al.
Nat Cell Biol
. 2020 Aug;
22(9):1064-1075.
PMID: 32839551
Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours. However,...
18.
Cheng J, Guo J, North B, Wang B, Cui C, Li H, et al.
Biochim Biophys Acta Rev Cancer
. 2019 Aug;
1872(2):188312.
PMID: 31449841
Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases. Currently, DUBs have been found to play critical...
19.
Cabrera J, Manivanh R, North B, Leib D
mBio
. 2019 Mar;
10(2).
PMID: 30837340
Interferons (IFNs) and autophagy are critical neuronal defenses against viral infection. IFNs alter neuronal autophagy by promoting the accumulation of IFN-dependent LC3-decorated autophagic structures, termed LC3 clusters. Here, we analyzed...
20.
Charron A, Ward S, North B, Ceron S, Leib D
J Virol
. 2019 Feb;
93(9).
PMID: 30760571
Herpes simplex virus 1 (HSV-1) cycles between phases of latency in sensory neurons and replication in mucosal sites. HSV-1 encodes two key proteins that antagonize the shutdown of host translation,...