Brian J Engel
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Explore the profile of Brian J Engel including associated specialties, affiliations and a list of published articles.
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20
Citations
171
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Recent Articles
1.
Engel B, Paolillo V, Uddin M, Gonzales K, McGinnis K, Sutton M, et al.
Cancers (Basel)
. 2023 Aug;
15(15).
PMID: 37568603
The worldwide incidence of hepatocellular carcinoma (HCC) continues to rise, in part due to poor diet, limited exercise, and alcohol abuse. Numerous studies have suggested that the loss or mutation...
2.
Chen C, Chin R, Hartley G, Lea S, Engel B, Hsieh C, et al.
Neuro Oncol
. 2023 Jan;
25(8):1415-1427.
PMID: 36705543
Background: The lack of murine glioblastoma models that mimic the immunobiology of human disease has impeded basic and translational immunology research. We, therefore, developed murine glioblastoma stem cell lines derived...
3.
Pollard A, Paolillo V, Radaram B, Qureshy S, Li L, Maity T, et al.
Mol Imaging Biol
. 2022 Jun;
24(6):959-972.
PMID: 35732988
Purpose: Metabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission tomography (PET) reporters are not used clinically to visualize altered...
4.
Grindel B, Engel B, Ong J, Srinivasamani A, Liang X, Zacharias N, et al.
ACS Chem Biol
. 2022 May;
17(6):1543-1555.
PMID: 35611948
Therapeutic monoclonal antibodies directed against PD-L1 (e.g., atezolizumab) disrupt PD-L1:PD-1 signaling and reactivate exhausted cytotoxic T-cells in the tumor compartment. Although anti-PD-L1 antibodies are successful as immune checkpoint inhibitor (ICI)...
5.
Gray J, Uddin M, Chaudhari R, Sutton M, Yang H, Rask P, et al.
Chem Sci
. 2021 Jun;
12(10):3526-3543.
PMID: 34163626
In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy in many cancer types. Unfortunately, chloroquine...
6.
Grindel B, Engel B, Hall C, Kelderhouse L, Lucci A, Zacharias N, et al.
ACS Omega
. 2020 Oct;
5(39):25440-25455.
PMID: 33043224
Directed evolution is a powerful tool for the selection of functional ligands from molecular libraries. Extracellular domains (ECDs) of cell surface receptors are common selection targets for therapeutic and imaging...
7.
Engel B, Preusch K, Brown C, Cramer C, Shoup R
J Chromatogr B Analyt Technol Biomed Life Sci
. 2020 Aug;
1154:122291.
PMID: 32763847
Bempedoic acid, a new therapeutic for treatment of hypercholesterolemia, inhibits hepatic ATP-citrate lyase in the cholesterol synthesis pathway after its conjugation with coenzyme A. Sensitive and selective methods were required...
8.
Gammon S, Engel B, Gores G, Cressman E, Piwnica-Worms D, Millward S
Mol Imaging Biol
. 2020 Jun;
22(5):1310-1323.
PMID: 32519246
Purpose: Apoptosis, in the context of cancer, is a form of programmed cell death induced by chemotherapy, radiotherapy, and immunotherapy. As this is a central pathway in treatment response, considerable...
9.
Kamalinia G, Engel B, Srinivasamani A, Grindel B, Ong J, Curran M, et al.
ACS Chem Biol
. 2020 May;
15(6):1630-1641.
PMID: 32352272
Programmed death ligand 1 (PD-L1) is a critical immune checkpoint ligand whose overexpression on tumor cells provides a mechanism of escape from immune surveillance. The interaction between PD-L1 and PD-1...
10.
Engel B, Grindel B, Gray J, Millward S
Bioorg Med Chem Lett
. 2020 Jan;
30(4):126934.
PMID: 31919017
Solid-phase resins functionalized with poly-deoxythymidine (dT) oligos facilitate purification of poly-adenylated molecules from solution through high affinity, high selectivity base-pairing interactions. These resins are commonly used to purify messenger RNA...