Nicholas Kwiatkowski
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Explore the profile of Nicholas Kwiatkowski including associated specialties, affiliations and a list of published articles.
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40
Citations
3188
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Recent Articles
1.
Lu W, Fan M, Ji W, Tse J, You I, Ficarro S, et al.
J Med Chem
. 2023 Mar;
66(7):4617-4632.
PMID: 36946421
Transcriptional enhanced associate domain (TEAD) proteins together with their transcriptional coactivator yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) are important transcription factors and cofactors that regulate...
2.
Yao Y, Ng J, Park W, Samur M, Morelli E, Encinas Mayoral J, et al.
Blood
. 2023 Mar;
141(23):2841-2852.
PMID: 36877894
Therapeutic targeting of CDK7 has proven beneficial in preclinical studies, yet the off-target effects of currently available CDK7 inhibitors make it difficult to pinpoint the exact mechanisms behind MM cell...
3.
Gao Y, Volegova M, Nasholm N, Das S, Kwiatkowski N, Abraham B, et al.
Front Oncol
. 2022 Feb;
11:773186.
PMID: 35198433
Purpose: Cyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a...
4.
Vervoort S, Devlin J, Kwiatkowski N, Teng M, Gray N, Johnstone R
Nat Rev Cancer
. 2021 Oct;
22(1):5-24.
PMID: 34675395
Accurate control of gene expression is essential for normal development and dysregulation of transcription underpins cancer onset and progression. Similar to cell cycle regulation, RNA polymerase II-driven transcription can be...
5.
Jiang B, Gao Y, Che J, Lu W, Kaltheuner I, Dries R, et al.
Nat Chem Biol
. 2021 Mar;
17(6):675-683.
PMID: 33753926
Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, development of selective small molecules targeting CDK12 has...
6.
Fan Z, Devlin J, Hogg S, Doyle M, Harrison P, Todorovski I, et al.
Sci Adv
. 2020 Sep;
6(18).
PMID: 32917631
The RNA polymerase II (POLII)-driven transcription cycle is tightly regulated at distinct checkpoints by cyclin-dependent kinases (CDKs) and their cognate cyclins. The molecular events underpinning transcriptional elongation, processivity, and the...
7.
Zhang H, Christensen C, Dries R, Oser M, Deng J, Diskin B, et al.
Cancer Cell
. 2019 Dec;
37(1):37-54.e9.
PMID: 31883968
Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene transcription. However, little is known about its impact on genomic instability and cancer immunity. Using a...
8.
Krajewska M, Dries R, Grassetti A, Dust S, Gao Y, Huang H, et al.
Nat Commun
. 2019 Apr;
10(1):1757.
PMID: 30988284
Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR)...
9.
Olson C, Liang Y, Leggett A, Park W, Li L, Mills C, et al.
Cell Chem Biol
. 2019 Mar;
26(6):792-803.e10.
PMID: 30905681
Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but its precise role remains elusive. We previously described THZ1, a CDK7 inhibitor, which dramatically inhibits superenhancer-associated gene expression. However,...
10.
Pitts J, Hsia C, Lian W, Wang J, Pfeil M, Kwiatkowski N, et al.
Antiviral Res
. 2019 Feb;
164:147-153.
PMID: 30771406
The recent emergence of Zika virus, a mosquito-borne flavivirus, in the Americas has shed light on the severe neurological diseases associated with infection, notably congenital microcephaly in newborns and Guillain-Barré...