Brian Glenn St Hilaire
Overview
Explore the profile of Brian Glenn St Hilaire including associated specialties, affiliations and a list of published articles.
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6
Citations
1484
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Recent Articles
1.
Hoencamp C, Dudchenko O, Elbatsh A, Brahmachari S, Raaijmakers J, van Schaik T, et al.
Science
. 2021 May;
372(6545):984-989.
PMID: 34045355
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during...
2.
Wutz G, Ladurner R, St Hilaire B, Stocsits R, Nagasaka K, Pignard B, et al.
Elife
. 2020 Feb;
9.
PMID: 32065581
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed...
3.
Vian L, Pekowska A, Rao S, Kieffer-Kwon K, Jung S, Baranello L, et al.
Cell
. 2018 Sep;
175(1):292-294.
PMID: 30241609
No abstract available.
4.
Vian L, Pekowska A, Rao S, Kieffer-Kwon K, Jung S, Baranello L, et al.
Cell
. 2018 May;
173(5):1165-1178.e20.
PMID: 29706548
Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in vivo, and thus, its functional impact and...
5.
Rao S, Huang S, St Hilaire B, Engreitz J, Perez E, Kieffer-Kwon K, et al.
Cell
. 2017 Oct;
171(2):305-320.e24.
PMID: 28985562
The human genome folds to create thousands of intervals, called "contact domains," that exhibit enhanced contact frequency within themselves. "Loop domains" form because of tethering between two loci-almost always bound...
6.
Kieffer-Kwon K, Nimura K, Rao S, Xu J, Jung S, Pekowska A, et al.
Mol Cell
. 2017 Aug;
67(4):566-578.e10.
PMID: 28803781
50 years ago, Vincent Allfrey and colleagues discovered that lymphocyte activation triggers massive acetylation of chromatin. However, the molecular mechanisms driving epigenetic accessibility are still unknown. We here show that...