Brian E Toki
Overview
Explore the profile of Brian E Toki including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
1085
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Burke P, Hamilton J, Pires T, Setter J, Hunter J, Cochran J, et al.
Mol Cancer Ther
. 2016 Mar;
15(5):938-45.
PMID: 26944920
A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody-drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The...
2.
Okeley N, Toki B, Zhang X, Jeffrey S, Burke P, Alley S, et al.
Bioconjug Chem
. 2013 Sep;
24(10):1650-5.
PMID: 24050213
The role that carbohydrates play in antibody function and pharmacokinetics has made them important targets for modification. The terminal fucose of the N-linked glycan structure, which has been shown to...
3.
Okeley N, Alley S, Anderson M, Boursalian T, Burke P, Emmerton K, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(14):5404-9.
PMID: 23493549
The key role played by fucose in glycoprotein and cellular function has prompted significant research toward identifying recombinant and biochemical strategies for blocking its incorporation into proteins and membrane structures....
4.
Burke P, Senter P, Meyer D, Miyamoto J, Anderson M, Toki B, et al.
Bioconjug Chem
. 2009 May;
20(6):1242-50.
PMID: 19469529
Antibody-drug conjugates (ADCs) were prepared with potent camptothecin analogues attached to monoclonal antibodies (mAbs) via dipeptide or glucuronide-based linkers. Aniline-containing camptothecin analogues were employed to provide a site of linker...
5.
Burke P, Toki B, Meyer D, Miyamoto J, Kissler K, Anderson M, et al.
Bioorg Med Chem Lett
. 2009 Apr;
19(10):2650-3.
PMID: 19386499
Cytotoxic agents streptonigrin and 17-amino-geldanamycin were linked to monoclonal antibodies (mAbs), forming antibody-drug conjugates (ADCs) for antigen-mediated targeting to cancer cells. The drugs were conjugated with a linker construct that...
6.
Alderson R, Toki B, Roberge M, Geng W, Basler J, Chin R, et al.
Bioconjug Chem
. 2006 Mar;
17(2):410-8.
PMID: 16536473
CC49 is a clinically validated antibody with specificity for TAG-72, a carbohydrate epitope that is overexpressed and exposed on the cell surface in a large fraction of solid malignancies. We...
7.
Law C, Gordon K, Toki B, Yamane A, Hering M, Cerveny C, et al.
Cancer Res
. 2006 Feb;
66(4):2328-37.
PMID: 16489038
Metastatic renal cell carcinoma (RCC) is an aggressive disease refractory to most existing therapeutic modalities. Identifying new markers for disease progression and drug targets for RCC will benefit this unmet...
8.
Doronina S, Mendelsohn B, Bovee T, Cerveny C, Alley S, Meyer D, et al.
Bioconjug Chem
. 2006 Jan;
17(1):114-24.
PMID: 16417259
We have previously shown that antibody-drug conjugates (ADCs) consisting of cAC10 (anti-CD30) linked to the antimitotic agent monomethylauristatin E (MMAE) lead to potent in vitro and in vivo activities against...
9.
Doronina S, Toki B, Torgov M, Mendelsohn B, Cerveny C, Chace D, et al.
Nat Biotechnol
. 2003 Jun;
21(7):778-84.
PMID: 12778055
We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic dolastatin 10 analogs auristatin E (AE) and monomethylauristatin E (MMAE), linked...
10.
Francisco J, Cerveny C, Meyer D, Mixan B, Klussman K, Chace D, et al.
Blood
. 2003 Apr;
102(4):1458-65.
PMID: 12714494
The chimeric monoclonal antibody cAC10, directed against CD30, induces growth arrest of CD30+ cell lines in vitro and has pronounced antitumor activity in severe combined immunodeficiency (SCID) mouse xenograft models...