Joseph A Francisco
Overview
Explore the profile of Joseph A Francisco including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
1275
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Recent Articles
1.
McDonagh C, Turcott E, Westendorf L, Webster J, Alley S, Kim K, et al.
Protein Eng Des Sel
. 2006 Apr;
19(7):299-307.
PMID: 16644914
The chimeric anti-CD30 IgG1, cAC10, conjugated to eight equivalents of monomethyl auristatin E (MMAE) was previously shown to have potent antitumor activity against CD30-expressing tumors xenografts in mice. Moreover, the...
2.
Law C, Gordon K, Toki B, Yamane A, Hering M, Cerveny C, et al.
Cancer Res
. 2006 Feb;
66(4):2328-37.
PMID: 16489038
Metastatic renal cell carcinoma (RCC) is an aggressive disease refractory to most existing therapeutic modalities. Identifying new markers for disease progression and drug targets for RCC will benefit this unmet...
3.
Law C, Cerveny C, Gordon K, Klussman K, Mixan B, Chace D, et al.
Clin Cancer Res
. 2004 Dec;
10(23):7842-51.
PMID: 15585616
The anti-CD20 antibody rituximab is useful in the treatment of certain B-cell malignancies, most notably non-Hodgkin's lymphoma. Its efficacy has been increased when used in combination with chemotherapy, yet anti-CD20...
4.
Hamblett K, Senter P, Chace D, Sun M, Lenox J, Cerveny C, et al.
Clin Cancer Res
. 2004 Oct;
10(20):7063-70.
PMID: 15501986
Purpose: An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE) conjugated to the anti-CD30 monoclonal antibody (mAb) cAC10, with eight drug moieties per mAb, was previously shown to have potent...
5.
McDonagh C, Beam K, Wu G, Chen J, Chace D, Senter P, et al.
Bioconjug Chem
. 2003 Sep;
14(5):860-9.
PMID: 13129388
The L49 single-chain Fv fused to beta-lactamase (L49-sFv-bL) combined with the prodrug C-Mel is an effective anticancer agent against tumor cells expressing the p97 antigen. However, large-scale production of L49-sFv-bL...
6.
Doronina S, Toki B, Torgov M, Mendelsohn B, Cerveny C, Chace D, et al.
Nat Biotechnol
. 2003 Jun;
21(7):778-84.
PMID: 12778055
We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic dolastatin 10 analogs auristatin E (AE) and monomethylauristatin E (MMAE), linked...
7.
Francisco J, Cerveny C, Meyer D, Mixan B, Klussman K, Chace D, et al.
Blood
. 2003 Apr;
102(4):1458-65.
PMID: 12714494
The chimeric monoclonal antibody cAC10, directed against CD30, induces growth arrest of CD30+ cell lines in vitro and has pronounced antitumor activity in severe combined immunodeficiency (SCID) mouse xenograft models...
8.
Wahl A, Klussman K, Thompson J, Chen J, Francisco L, Risdon G, et al.
Cancer Res
. 2002 Jul;
62(13):3736-42.
PMID: 12097283
The leukocyte activation marker CD30 is highly expressed on the Reed Sternberg cells of Hodgkin's disease (HD). On normal tissues, CD30 has a restricted expression profile limited to activated T...