Brian D Janssen
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Explore the profile of Brian D Janssen including associated specialties, affiliations and a list of published articles.
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11
Citations
384
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Recent Articles
1.
Janssen B, Chen Y, Molgora B, Wang S, Simoes-Barbosa A, Johnson P
Sci Rep
. 2018 Jan;
8(1):270.
PMID: 29321601
The sexually-transmitted parasite Trichomonas vaginalis infects ~1/4 billion people worldwide. Despite its prevalence and myriad adverse outcomes of infection, the mechanisms underlying T. vaginalis pathogenesis are poorly understood. Genetic manipulation...
2.
Janssen B, Garza-Sanchez F, Hayes C
Microbiologyopen
. 2015 Jul;
4(4):682-97.
PMID: 26147890
Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change. Here, we show that YoeB, a...
3.
Janssen B, Garza-Sanchez F, Hayes C
PLoS One
. 2013 Nov;
8(11):e81319.
PMID: 24260569
In Escherichia coli, prolonged translational arrest allows mRNA degradation into the A site of stalled ribosomes. The enzyme that cleaves the A-site codon is not known, but its activity requires...
4.
Leitsch D, Janssen B, Kolarich D, Johnson P, Duchene M
Mol Microbiol
. 2013 Nov;
91(1):198-208.
PMID: 24256032
The enzyme flavin reductase 1 (FR1) from Trichomonas vaginalis, formerly known as NADPH oxidase, was isolated and identified. Flavin reductase is part of the antioxidative defence in T. vaginalis and...
5.
Janssen B, Diner E, Hayes C
Methods Mol Biol
. 2012 Jun;
905:291-309.
PMID: 22736012
During protein synthesis, ribosomes translate the genetic information encoded within messenger RNAs into defined amino acid sequences. Transfer RNAs (tRNAs) are crucial adaptor molecules in this process, delivering amino acid...
6.
Janssen B, Hayes C
Adv Protein Chem Struct Biol
. 2012 Jan;
86:151-91.
PMID: 22243584
The bacterial tmRNA quality control system monitors protein synthesis and recycles stalled translation complexes in a process termed "ribosome rescue." During rescue, tmRNA acts first as a transfer RNA to...
7.
Seidman J, Janssen B, Hayes C
J Biol Chem
. 2011 Jul;
286(36):31105-12.
PMID: 21757758
The bacterial tmRNA·SmpB system facilitates recycling of stalled translational complexes in a process termed "ribosome rescue." During ribosome rescue, the nascent chain is tagged with the tmRNA-encoded ssrA peptide, which...
8.
Garza-Sanchez F, Schaub R, Janssen B, Hayes C
Mol Microbiol
. 2011 Mar;
80(5):1204-19.
PMID: 21435036
Translation of mRNA lacking an in-frame stop codon leads to ribosome arrest at the 3' end of the transcript. In bacteria, the tmRNA quality control system recycles these stalled ribosomes...
9.
Shoji S, Janssen B, Hayes C, Fredrick K
Biochimie
. 2009 Nov;
92(2):157-63.
PMID: 19925844
LepA is a translational GTPase highly conserved in bacterial lineages. While it has been shown that LepA can catalyze reverse ribosomal translocation in vitro, the role of LepA in the...
10.
Janssen B, Hayes C
J Mol Biol
. 2009 Sep;
394(2):251-67.
PMID: 19761774
The bacterial tmRNA.SmpB system recycles stalled translation complexes in a process termed 'ribosome rescue.' tmRNA.SmpB specifically recognizes ribosomes that are paused at or near the 3' end of truncated mRNA;...