David Leitsch
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Explore the profile of David Leitsch including associated specialties, affiliations and a list of published articles.
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55
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974
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Recent Articles
1.
Paunkov A, Strasser D, Huber P, Leitsch D
Parasitol Res
. 2025 Feb;
124(2):21.
PMID: 39937247
Trichomonas vaginalis infections significantly impact public health and are associated with increased likelihood of HIV infection, prostate cancer, and pregnancy complications. Current treatment relies almost exclusively on 5-nitroimidazoles, particularly metronidazole,...
2.
Starynets K, Paunkov A, Wagner A, Kratochwill K, Klotz C, Leitsch D
Int J Parasitol Drugs Drug Resist
. 2025 Feb;
27:100585.
PMID: 39904006
The microaerophilic/anaerobic protist Giardia lamblia is a world-wide occurring parasite of the human small intestine. It causes giardiasis which manifests as diarrhoea accompanied by other sequelae. Giardiasis is most commonly...
3.
Mayr A, Paunkov A, Hummel K, Razzazi-Fazeli E, Leitsch D
Int J Parasitol Drugs Drug Resist
. 2024 Oct;
26:100566.
PMID: 39368438
The microaerophilic parasite Trichomonas vaginalis occurs worldwide and causes inflammation of the urogenital tract, especially in women. With 156 million infections annually, trichomoniasis is the most prevalent non-viral sexually transmitted...
4.
Loufouma-Mbouaka A, Andor A, Leitsch D, Perez-Serrano J, Arner E, Walochnik J, et al.
Int J Parasitol Drugs Drug Resist
. 2024 Sep;
26:100564.
PMID: 39326195
The genus Acanthamoeba comprises facultative pathogens, causing Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). In both diseases, treatment options are limited, and drug development is challenging. This study aimed...
5.
Mahmood B, Paunkov A, Kupc M, Burian K, Nagy E, Leitsch D, et al.
Antibiotics (Basel)
. 2024 Mar;
13(3).
PMID: 38534642
Previously, we reported that metronidazole MICs are not dependent on the expression levels of genes in strains and we compared the proteomes of metronidazole-resistant laboratory strains to those of their...
6.
Mayr A, Hummel K, Leitsch D, Razzazi-Fazeli E
ACS Omega
. 2024 Mar;
9(8):9782-9791.
PMID: 38434803
Bottom-up proteomic approaches depend on the efficient digestion of proteins into peptides for mass spectrometric analysis. Sample preparation strategies, based on magnetic beads, filter-aided systems, or in-solution digests, are commonly...
7.
Mahmood B, Juhasz H, Leitsch D, Soki J
Anaerobe
. 2023 May;
81:102739.
PMID: 37209770
In this study we examined whether the same nim gene-insertion sequence (IS) element combinations give rise to the same expression levels as they harbor shared IS element-borne promoters. From our...
8.
Paunkov A, Hummel K, Strasser D, Soki J, Leitsch D
Front Microbiol
. 2023 Apr;
14:1158086.
PMID: 37065137
The anaerobic gut bacteria and opportunistic pathogen can cause life-threatening infections when leaving its niche and reaching body sites outside of the gut. The antimicrobial metronidazole is a mainstay in...
9.
Kupc M, Paunkov A, Strasser D, Soki J, Leitsch D
Anaerobe
. 2022 Aug;
77:102630.
PMID: 36028117
Objectives: In the genus Bacteroides, the nim genes are resistance determinants for metronidazole, a nitroimidazole drug widely used against anaerobic pathogens. The Nim proteins are considered to act as nitroreductases....
10.
Paunkov A, Soki J, Leitsch D
Front Microbiol
. 2022 Jun;
13:898453.
PMID: 35756037
is a commensal of the human gut but can also cause severe infections when reaching other body sites, especially after surgery or intestinal trauma. is an anaerobe innately susceptible to...