Brett A Vaughn
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Explore the profile of Brett A Vaughn including associated specialties, affiliations and a list of published articles.
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14
Citations
144
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Recent Articles
1.
Vaughn B, Lee S, Vargas D, Seo S, Rinne S, Xu H, et al.
J Nucl Med
. 2024 Aug;
65(10):1611-1618.
PMID: 39168519
Radiolabeled small-molecule DOTA-haptens can be combined with antitumor/anti-DOTA bispecific antibodies (BsAbs) for pretargeted radioimmunotherapy (PRIT). For optimized delivery of the theranostic γ- and β-emitting isotope Lu with DOTA-based PRIT (DOTA-PRIT),...
2.
Chung S, Vargas D, Chandler C, Katugampola S, Veach D, McDevitt M, et al.
J Nucl Med
. 2023 Jun;
64(9):1439-1445.
PMID: 37348919
Epithelial ovarian cancer (EOC) is often asymptomatic and presents clinically in an advanced stage as widespread peritoneal microscopic disease that is generally considered to be surgically incurable. Targeted α-therapy with...
3.
Cheal S, Chung S, Vaughn B, Cheung N, Larson S
J Nucl Med
. 2022 Oct;
63(9):1302-1315.
PMID: 36215514
Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high-therapeutic-index (TI) tumor targeting, respectively. As opposed to conventional radioimmunoconjugates, pretargeted approaches separate...
4.
Whetter J, Vaughn B, Koller A, Boros E
Angew Chem Int Ed Engl
. 2021 Dec;
61(7):e202114203.
PMID: 34889014
Fluorine-18 remains the most widely clinically utilized radionuclide globally for positron emission tomography (PET). The emergence of therapeutic isotopes for the management of disease has produced a pronounced interest in...
5.
Vaughn B, Loveless C, Cingoranelli S, Schlyer D, Lapi S, Boros E
Mol Pharm
. 2021 Oct;
18(12):4511-4519.
PMID: 34714082
Lu-177-based, targeted radiotherapeutics/endoradiotherapies are an emerging clinical tool for the management of various cancers. The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) remains the workhorse for such applications but can limit apparent molar...
6.
Vaughn B, Koller A, Boros E
Methods Enzymol
. 2021 Apr;
651:343-371.
PMID: 33888209
The aqueous chemistry of scandium(III) is of emerging interest for biological applications, specifically in nuclear medicine, as radioactive isotopes of scandium are becoming more readily accessible. In contrast to other...
7.
Vaughn B, Koller A, Chen Z, Ahn S, Loveless C, Cingoranelli S, et al.
Bioconjug Chem
. 2020 Dec;
32(7):1232-1241.
PMID: 33284001
The radioactive isotopes scandium-44/47 and lutetium-177 are gaining relevance for radioimaging and radiotherapy, resulting in a surge of studies on their coordination chemistry and subsequent applications. Although the trivalent ions...
8.
Vaughn B, Brown A, Ahn S, Robinson J, Boros E
Inorg Chem
. 2020 Oct;
59(22):16095-16108.
PMID: 33112609
A growing number of copper(II) complexes have been identified as suitable candidates for biomedical applications. Here, we show that the biocompatibility and stability of copper(II) complexes can be tuned by...
9.
Vaughn B, Ahn S, Aluicio-Sarduy E, Devaraj J, Olson A, Engle J, et al.
Chem Sci
. 2020 Sep;
11(2):333-342.
PMID: 32953004
Scandium-44 has emerged as an attractive, novel PET radioisotope with ideal emission properties and half-life ( = 3.97 h, β = 632 keV) well matched to the pharmacokinetics of small...
10.
Konkankit C, Vaughn B, Huang Z, Boros E, Wilson J
Dalton Trans
. 2020 Apr;
49(45):16062-16066.
PMID: 32319485
Rhenium-based anticancer agents have arisen as promising alternatives to conventional platinum-based drugs. Based on previous studies demonstrating how increasing lipophilicity improves drug uptake within the cell, we sought to investigate...