Brenton R Ware
Overview
Explore the profile of Brenton R Ware including associated specialties, affiliations and a list of published articles.
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12
Citations
345
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Recent Articles
1.
Ware B, Liu J, Monckton C, Ballinger K, Khetani S
Toxicol Sci
. 2021 Feb;
181(1):90-104.
PMID: 33590212
Human liver models are useful for assessing compound metabolism/toxicity; however, primary human hepatocyte (PHH) lots are limited and highly variable in quality/viability. In contrast, cell lines, such as HepaRG, are...
2.
Ware B, Brown G, Soldatow V, LeCluyse E, Khetani S
Gene Expr
. 2020 Jun;
20(1):75-76.
PMID: 32522329
Testing drugs in isogenic rodent strains to satisfy regulatory requirements is insufficient for derisking organ toxicity in genetically diverse human populations; in contrast, advances in mouse genetics can help mitigate...
3.
Ware B, Brown G, Soldatow V, LeCluyse E, Khetani S
Gene Expr
. 2019 Jul;
19(3):199-214.
PMID: 31340881
Testing drugs in isogenic rodent strains to satisfy regulatory requirements is insufficient for derisking organ toxicity in genetically diverse human populations; in contrast, advances in mouse genetics can help mitigate...
4.
Ware B, Durham M, Monckton C, Khetani S
Cell Mol Gastroenterol Hepatol
. 2018 Jan;
5(3):187-207.
PMID: 29379855
Background And Aims: Modeling interactions between primary human hepatocytes (PHHs) and primary human liver sinusoidal endothelial cells (LSECs) can help elucidate human-specific mechanisms underlying liver physiology/disease and drug responses; however,...
5.
Mosedale M, Eaddy J, Trask Jr O, Holman N, Wolf K, LeCluyse E, et al.
Toxicol Sci
. 2017 Oct;
161(1):149-158.
PMID: 29029277
Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in...
6.
Ware B, McVay M, Sunada W, Khetani S
Toxicol Sci
. 2017 Apr;
157(2):387-398.
PMID: 28369597
Global gene expression profiling is useful for elucidating a drug's mechanism of action on the liver; however, such profiling in rats is not very sensitive for predicting human drug-induced liver...
7.
Ware B, Khetani S
Trends Biotechnol
. 2016 Sep;
35(2):172-183.
PMID: 27592803
Drug-induced liver injury (DILI) remains a leading cause of drug withdrawal from human clinical trials or the marketplace. Owing to species-specific differences in liver pathways, predicting human-relevant DILI using in...
8.
Neufeld M, Ware B, Lutzke A, Khetani S, Reynolds M
ACS Appl Mater Interfaces
. 2016 Jul;
8(30):19343-52.
PMID: 27447022
Metal-organic frameworks (MOFs) have demonstrated promise in biomedical applications as vehicles for drug delivery, as well as for the ability of copper-based MOFs to generate nitric oxide (NO) from endogenous...
9.
Davidson M, Ware B, Khetani S
Discov Med
. 2015 Jun;
19(106):349-58.
PMID: 26105698
Differences between animals and humans in liver pathways now necessitate the use of in vitro models of the human liver for several applications such as drug screening. However, isolated primary...
10.
Ware B, Berger D, Khetani S
Toxicol Sci
. 2015 Feb;
145(2):252-62.
PMID: 25716675
Primary human hepatocytes (PHHs) are a limited resource for drug screening, their quality for in vitro use can vary considerably across different lots, and a lack of available donor diversity...