Edward L LeCluyse
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Explore the profile of Edward L LeCluyse including associated specialties, affiliations and a list of published articles.
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63
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2515
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Recent Articles
1.
Odanga J, Anderson S, Presnell S, LeCluyse E, Chen J, Weaver J
Pharmaceuticals (Basel)
. 2025 Jan;
17(12.
PMID: 39770467
: Liver diseases are a global health concern. Many in vitro liver models utilize cryopreserved primary human hepatocytes (PHHs), which commonly undergo post-thaw processing through colloidal silica gradients to remove...
2.
Odanga J, Anderson S, Breathwaite E, Presnell S, LeCluyse E, Chen J, et al.
Sci Rep
. 2024 Mar;
14(1):6772.
PMID: 38514705
Liver diseases, including NAFLD, are a growing worldwide health concern. Currently, there is a lack of suitable in vitro models that sustain basic primary human hepatocyte (PHH) morphology and functionality...
3.
Odanga J, Gianulis E, Whaley L, LeCluyse E, Presnell S, Weaver J
J Vis Exp
. 2023 Nov;
(200).
PMID: 37930008
Finding a long-term, human-relevant culture model for primary human hepatocytes (PHHs) for pharmacological and toxicological studies remains a challenge. Current in vitro model platforms are often inconvenient and complex, lack...
4.
Filipovic D, Qi W, Kana O, Marri D, LeCluyse E, Andersen M, et al.
Toxicol Sci
. 2023 Sep;
196(2):170-186.
PMID: 37707797
The aryl hydrocarbon receptor (AhR) is an inducible transcription factor whose ligands include the potent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs) containing...
5.
Tao T, Maschmeyer I, LeCluyse E, Rogers E, Brandmair K, Gerlach S, et al.
Front Pharmacol
. 2023 Feb;
14:1076254.
PMID: 36843954
All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established...
6.
Weaver J, Odanga J, Wolf K, Piekos S, Biven M, Taub M, et al.
Toxicol In Vitro
. 2022 Oct;
86:105504.
PMID: 36288780
There remains a significant need for a convenient, phenotypically stable long-term culture platform for primary human hepatocytes (PHHs) for use in pharmacological and toxicological applications. Conventional in vitro models are...
7.
Olander M, Wegler C, Florkemeier I, Treyer A, Handin N, Pedersen J, et al.
J Cell Physiol
. 2021 Jan;
236(8):5885-5894.
PMID: 33452735
Human hepatocytes show marked differences in cell size, gene expression, and function throughout the liver lobules, an arrangement termed liver zonation. However, it is not clear if these zonal size...
8.
Ware B, Brown G, Soldatow V, LeCluyse E, Khetani S
Gene Expr
. 2020 Jun;
20(1):75-76.
PMID: 32522329
Testing drugs in isogenic rodent strains to satisfy regulatory requirements is insufficient for derisking organ toxicity in genetically diverse human populations; in contrast, advances in mouse genetics can help mitigate...
9.
Deisenroth C, Soldatow V, Ford J, Stewart W, Brinkman C, LeCluyse E, et al.
Toxicol Sci
. 2019 Dec;
174(1):63-78.
PMID: 31808822
Thyroid hormones (TH) are essential for regulating a number of diverse physiological processes required for normal growth, development, and metabolism. The US EPA Endocrine Disruptor Screening Program (EDSP) has identified...
10.
McMullen P, Bhattacharya S, Woods C, Pendse S, McBride M, Soldatow V, et al.
Toxicol In Vitro
. 2019 Oct;
64:104463.
PMID: 31628012
In this paper, we evaluate the PPARα signaling network in rats, examining transcriptional responses in primary hepatocytes exposed to a PPARα specific ligand, GW7647. These transcriptomic studies were complemented with...