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Paul B Watkins

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Articles 167
Citations 5300
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Recent Articles
1.
Chalasani N, Hayashi P, Luffer-Atlas D, Regev A, Watkins P
Hepatology . 2025 Feb; PMID: 39999469
Drug-induced liver injury (DILI) is rare in clinical practice but when it occurs it can lead to acute liver failure and death. Drug developers and regulators undertake a series of...
2.
Hammond S, Meng X, Barber J, Mosedale M, Chadwick A, Watkins P, et al.
Toxicol Sci . 2024 Nov; 203(1):11-27. PMID: 39495155
Tolvaptan is a vasopressin V2 receptor antagonist which has proven to be an effective and mostly well-tolerated agent for the treatment of autosomal-dominant polycystic kidney disease. However, its administration is...
3.
Turner J, Pound P, Owen C, Hutchinson I, Hop M, Chau D, et al.
ALTEX . 2024 Nov; 41(4):674-675. PMID: 39484727
This corrects the article DOI: 10.14573/altex.2212081.
4.
Zaidman C, Goedeker N, Aqul A, Butterfield R, Connolly A, Crystal R, et al.
J Neuromuscul Dis . 2024 Apr; 11(3):687-699. PMID: 38607761
Background: Duchenne muscular dystrophy (DMD) is a rare, degenerative, recessive X-linked neuromuscular disease. Mutations in the gene encoding dystrophin lead to the absence of functional dystrophin protein. Individuals living with...
5.
Fontana R, Li Y, Vuppalanchi R, Kleiner D, Gu J, Shroff H, et al.
Am J Gastroenterol . 2024 Feb; 119(8):1496-1505. PMID: 38314748
Introduction: The aim of this study is to describe the presenting features, genetic factors, and outcomes of 23 adults who developed liver injury after coronavirus disease 2019 (COVID-19) mRNA vaccination....
6.
Yang K, Kong R, Spiegel R, Baird J, OKeefe K, Howell B, et al.
Clin Pharmacol Ther . 2023 Dec; 115(3):525-534. PMID: 38065572
Clinical investigation of emvododstat for the treatment of solid tumors was halted after two patients who were heavily treated with other anticancer therapies experienced drug-induced liver failure. However, preclinical investigations...
7.
Fecho K, Bizon C, Issabekova T, Moxon S, Thessen A, Abdollahi S, et al.
J Clin Transl Sci . 2023 Oct; 7(1):e214. PMID: 37900350
Knowledge graphs have become a common approach for knowledge representation. Yet, the application of graph methodology is elusive due to the sheer number and complexity of knowledge sources. In addition,...
8.
Battista C, Shoda L, Watkins P, Groettrup-Wolfers E, Rottmann A, Raschke M, et al.
Clin Pharmacol Ther . 2023 Jul; 114(5):1023-1032. PMID: 37501650
BAY1128688 is a selective inhibitor of AKR1C3, investigated recently in a trial that was prematurely terminated due to drug-induced liver injury. These unexpected observations prompted use of the quantitative systems...
9.
Lakhani V, Generaux G, Howell B, Longo D, Watkins P
Clin Pharmacol Ther . 2023 Jul; 114(5):1006-1014. PMID: 37458709
In clinical trials of cannabidiol (CBD) for the treatment of seizures in patients with Dravet syndrome, Lennox-Gastaut syndrome, and tuberous sclerosis complex, elevations in serum alanine aminotransferase (ALT) > 3×...
10.
Ghany M, Watkins P
JAMA . 2023 Mar; 329(9):713-715. PMID: 36881043
No abstract available.