Chase P Monckton
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Explore the profile of Chase P Monckton including associated specialties, affiliations and a list of published articles.
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8
Citations
105
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Recent Articles
1.
Brougham-Cook A, Kimmel H, Monckton C, Owen D, Khetani S, Underhill G
APL Bioeng
. 2022 Nov;
6(4):046102.
PMID: 36345318
Fibrosis is one of the hallmarks of chronic liver disease and is associated with aberrant wound healing. Changes in the composition of the liver microenvironment during fibrosis result in a...
2.
Monckton C, Brougham-Cook A, Underhill G, Khetani S
Acta Biomater
. 2022 Sep;
153:216-230.
PMID: 36115650
In vitro human liver models are essential for drug screening, disease modeling, and cell-based therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHeps) mitigate sourcing limitations of primary human hepatocytes...
3.
Panday R, Monckton C, Khetani S
Semin Liver Dis
. 2022 Feb;
42(1):1-16.
PMID: 35120381
As blood flows from the portal triad to the central vein, cell-mediated depletion establishes gradients of soluble factors such as oxygen, nutrients, and hormones, which act through molecular pathways (e.g.,...
4.
Monckton C, Brougham-Cook A, Kaylan K, Underhill G, Khetani S
Adv Mater Interfaces
. 2022 Feb;
8(22).
PMID: 35111564
How the liver's extracellular matrix (ECM) protein composition and stiffness cooperatively regulate primary human hepatocyte (PHH) phenotype is unelucidated. Here, we utilize protein microarrays and high content imaging with single-cell...
5.
Monckton C, Brown G, Khetani S
APL Bioeng
. 2021 Jul;
5(3):031506.
PMID: 34286173
Drug-induced liver injury (DILI) is a leading cause of drug attrition, which is partly due to differences between preclinical animals and humans in metabolic pathways. Therefore, human liver models are...
6.
Ware B, Liu J, Monckton C, Ballinger K, Khetani S
Toxicol Sci
. 2021 Feb;
181(1):90-104.
PMID: 33590212
Human liver models are useful for assessing compound metabolism/toxicity; however, primary human hepatocyte (PHH) lots are limited and highly variable in quality/viability. In contrast, cell lines, such as HepaRG, are...
7.
Dzhashiashvili Y, Monckton C, Shah H, Kunjamma R, Popko B
Neurobiol Dis
. 2019 Mar;
127:527-544.
PMID: 30923003
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for...
8.
Ware B, Durham M, Monckton C, Khetani S
Cell Mol Gastroenterol Hepatol
. 2018 Jan;
5(3):187-207.
PMID: 29379855
Background And Aims: Modeling interactions between primary human hepatocytes (PHHs) and primary human liver sinusoidal endothelial cells (LSECs) can help elucidate human-specific mechanisms underlying liver physiology/disease and drug responses; however,...