Bradley L Pentelute
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Explore the profile of Bradley L Pentelute including associated specialties, affiliations and a list of published articles.
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136
Citations
3037
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Recent Articles
21.
Ye X, Zhang P, Tao J, Wang J, Mafi A, Grob N, et al.
Chem Sci
. 2023 Nov;
14(44):12484-12497.
PMID: 38020382
Human papillomavirus (HPV) infections account for nearly all cervical cancer cases, which is the fourth most common cancer in women worldwide. High-risk variants, including HPV16, drive tumorigenesis in part by...
22.
Truex N, Rondon A, Rossler S, Hanna C, Cho Y, Wang B, et al.
ACS Cent Sci
. 2023 Oct;
9(9):1835-1845.
PMID: 37780364
Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of therapeutics that promote immunity against cancer and pathogenic diseases but often exhibit limited efficacy. Here, we engineered...
23.
Johnson K, Delaney J, Guillard T, Reffuveille F, Varin-Simon J, Li K, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011612.
PMID: 37676873
The increase in emerging drug resistant Gram-negative bacterial infections is a global concern. In addition, there is growing recognition that compromising the microbiota through the use of broad-spectrum antibiotics can...
24.
Truex N, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, et al.
bioRxiv
. 2023 Sep;
PMID: 37662211
Antigen processing is critical for producing epitope peptides that are presented by HLA molecules for T cell recognition. Therapeutic vaccines aim to harness these epitopes for priming cytotoxic T cell...
25.
Sato K, Farquhar C, Rodriguez J, Pentelute B
J Am Chem Soc
. 2023 Jun;
145(24):12992-12997.
PMID: 37294668
An expansion of the hexanucleotide (GGGGCC) repeat sequence in chromosome 9 open frame 72 () is the most common genetic mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)....
26.
Nomura K, Okamoto R, Maki Y, Hayashibara A, Takao T, Fukuoka T, et al.
Chemistry
. 2023 Jun;
29(42):e202300646.
PMID: 37294165
Serine protease inhibitor Kazal type 13 (SPINK13) is a secreted protein that has been recently studied as a therapeutic drug and an interesting biomarker for cancer cells. Although SPINK13 has...
27.
Schissel C, Farquhar C, Malmberg A, Loas A, Pentelute B
ACS Bio Med Chem Au
. 2023 Apr;
2(2):150-160.
PMID: 37101743
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant macromolecules such as proteins and oligonucleotides. For example, recent clinical trials have shown that...
28.
Ye X, Zhang P, Wang J, Smith C, Sousa S, Loas A, et al.
Angew Chem Int Ed Engl
. 2023 Mar;
62(19):e202300289.
PMID: 36894520
α-Klotho, an aging-related protein found in the kidney, parathyroid gland, and choroid plexus, acts as an essential co-receptor with the fibroblast growth factor 23 receptor complex to regulate serum phosphate...
29.
Rossler S, Grob N, Buchwald S, Pentelute B
Science
. 2023 Mar;
379(6635):939-945.
PMID: 36862767
Encoding small-molecule information in DNA has been leveraged to accelerate the discovery of ligands for therapeutic targets such as proteins. However, oligonucleotide-based encoding is hampered by inherent limitations of information...
30.
Schissel C, Farquhar C, Loas A, Malmberg A, Pentelute B
ACS Chem Biol
. 2023 Mar;
18(3):615-628.
PMID: 36857503
Peptide-mediated delivery of macromolecules in cells has significant potential therapeutic benefits, but no therapy employing cell-penetrating peptides (CPPs) has reached the market after 30 years of investigation due to challenges...