Bradley L Pentelute
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Explore the profile of Bradley L Pentelute including associated specialties, affiliations and a list of published articles.
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136
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3037
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Recent Articles
31.
Saebi A, Brown J, Marando V, Hartrampf N, Chumbler N, Hanna S, et al.
ACS Chem Biol
. 2023 Feb;
18(3):518-527.
PMID: 36821521
The impermeable outer membrane of is bypassed by antibacterial proteins known as S-type pyocins. Because of their properties, pyocins are investigated as a potential new class of antimicrobials against infections....
32.
Ye X, Lee Y, Gates Z, Ling Y, Mortensen J, Yang F, et al.
Commun Chem
. 2023 Jan;
5(1):128.
PMID: 36697672
Establishing structure-activity relationships is crucial to understand and optimize the activity of peptide-based inhibitors of protein-protein interactions. Single alanine substitutions provide limited information on the residues that tolerate simultaneous modifications...
33.
Zhang G, Brown J, Quartararo A, Li C, Tan X, Hanna S, et al.
Commun Chem
. 2023 Jan;
5(1):8.
PMID: 36697587
Rapid discovery and development of serum-stable, selective, and high affinity peptide-based binders to protein targets are challenging. Angiotensin converting enzyme 2 (ACE2) has recently been identified as a cardiovascular disease...
34.
Rojas A, Wolfe J, Dhanjee H, Buslov I, Truex N, Liu R, et al.
Chem Sci
. 2022 Nov;
13(40):11891-11895.
PMID: 36320916
The synthesis of palladium oxidative addition complexes derived from unprotected peptides is described. Incorporation of 4-halophenylalanine into a peptide during solid phase peptide synthesis allows for subsequent oxidative addition at...
35.
Li C, Zhang G, Mohapatra S, Callahan A, Loas A, Gomez-Bombarelli R, et al.
Adv Sci (Weinh)
. 2022 Oct;
9(34):e2201988.
PMID: 36270977
Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands...
36.
Backlund C, Holden R, Moynihan K, Garafola D, Farquhar C, Mehta N, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(32):e2204078119.
PMID: 35914154
Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest immunogenicity. One approach that has been explored to enhance peptide vaccine potency is covalent conjugation of antigens with...
37.
Rodriguez J, Dhanjee H, Pentelute B, Buchwald S
J Am Chem Soc
. 2022 Jun;
144(26):11706-11712.
PMID: 35749644
Catalyst transfer polymerization (CTP) is widely applied to the synthesis of well-defined π-conjugated polymers. Unlike other polymerization reactions that can be performed in water (e.g., controlled radical polymerizations and ring-opening...
38.
Gazvoda M, Dhanjee H, Rodriguez J, Brown J, Farquhar C, Truex N, et al.
J Am Chem Soc
. 2022 May;
144(22):10096.
PMID: 35639117
No abstract available.
39.
Cho C, Farquhar C, Fadzen C, Scott B, Zhuang P, von Spreckelsen N, et al.
Cancers (Basel)
. 2022 May;
14(9).
PMID: 35565337
Background: Glioblastoma (GBM) is the most common and deadliest malignant primary brain tumor, contributing significant morbidity and mortality among patients. As current standard-of-care demonstrates limited success, the development of new...
40.
Gazvoda M, Dhanjee H, Rodriguez J, Brown J, Farquhar C, Truex N, et al.
J Am Chem Soc
. 2022 Apr;
144(17):7852-7860.
PMID: 35438502
Carboranes represent a class of compounds with increasing therapeutic potential. However, few general approaches to readily embed carboranes into small molecules, peptides, and proteins are available. We report a strategy...