Bradley L Pentelute
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Explore the profile of Bradley L Pentelute including associated specialties, affiliations and a list of published articles.
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136
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3037
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Recent Articles
11.
Velez-Arce A, Li M, Gao W, Lin X, Huang K, Fu T, et al.
bioRxiv
. 2024 Jul;
PMID: 38948789
Drug discovery AI datasets and benchmarks have not traditionally included single-cell analysis biomarkers. While benchmarking efforts in single-cell analysis have recently released collections of single-cell tasks, they have yet to...
12.
Miao J, Ghosh A, Ho M, Li C, Huang X, Pentelute B, et al.
J Phys Chem B
. 2024 May;
128(22):5281-5292.
PMID: 38785765
Molecular dynamics simulation is a powerful tool for characterizing the solution structural ensembles of cyclic peptides. However, the ability of simulation to recapitulate experimental results and make accurate predictions largely...
13.
Zhang P, Ye X, Wang J, Baddock H, Jensvold Z, Foe I, et al.
J Am Chem Soc
. 2024 May;
146(22):15627-15639.
PMID: 38771982
Covalent peptide binders have found applications as activity-based probes and as irreversible therapeutic inhibitors. Currently, there is no rapid, label-free, and tunable affinity selection platform to enrich covalent reactive peptide...
14.
Truex N, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, et al.
ACS Cent Sci
. 2024 Apr;
10(4):793-802.
PMID: 38680558
Antigen processing is critical for therapeutic vaccines to generate epitopes for priming cytotoxic T cell responses against cancer and pathogens, but insufficient processing often limits the quantity of epitopes released....
15.
Zhang P, Ye X, Wang J, Smith C, Sousa S, Loas A, et al.
JACS Au
. 2024 Apr;
4(4):1334-1344.
PMID: 38665650
The kidney, parathyroid gland, and choroid plexus express the aging-related transmembrane protein α-Klotho, a coreceptor of the fibroblast growth factor 23 (FGF23) receptor complex. Reduced α-Klotho levels are correlated with...
16.
Baxa M, Lin X, Mukinay C, Chakravarthy S, Sachleben J, Antilla S, et al.
Protein Sci
. 2024 Apr;
33(5):e4986.
PMID: 38607226
Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrophobic content typical of foldable proteins, behave...
17.
Charalampidou A, Nehls T, Meyners C, Gandhesiri S, Pomplun S, Pentelute B, et al.
ACS Cent Sci
. 2024 Apr;
10(3):649-657.
PMID: 38559286
Engineering at the amino acid level is key to enhancing the properties of existing proteins in a desired manner. So far, protein engineering has been dominated by genetic approaches, which...
18.
Liu B, Rodriguez J, Kilgallon L, Wang W, Wang Y, Wang A, et al.
Chem Commun (Camb)
. 2024 Mar;
60(31):4238-4241.
PMID: 38529790
Polymer-protein bioconjugation offers a powerful strategy to alter the physical properties of proteins, and various synthetic polymer compositions and architectures have been investigated for this purpose. Nevertheless, conjugation of molecular...
19.
Callahan A, Gandhesiri S, Travaline T, Reja R, Salazar L, Hanna S, et al.
Nat Commun
. 2024 Feb;
15(1):1813.
PMID: 38418820
Widespread adoption of mirror-image biological systems presents difficulties in accessing the requisite D-protein substrates. In particular, mirror-image phage display has the potential for high-throughput generation of biologically stable macrocyclic D-peptide...
20.
Grob N, Remarcik C, Rossler S, Wong J, Wang J, Tao J, et al.
ACS Chem Biol
. 2023 Dec;
19(1):101-109.
PMID: 38069818
Protein-protein interactions (PPIs) are intriguing targets in drug discovery and development. Peptides are well suited to target PPIs, which typically present with large surface areas lacking distinct features and deep...