Bradley I Coleman
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Explore the profile of Bradley I Coleman including associated specialties, affiliations and a list of published articles.
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19
Citations
601
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Recent Articles
11.
Coleman B, Gubbels M
J Vis Exp
. 2012 Feb;
(60).
PMID: 22349295
The widespread, obligate intracellular, protozoan parasite Toxoplasma gondii causes opportunistic disease in immuno-compromised patients and causes birth defects upon congenital infection. The lytic replication cycle is characterized by three stages:...
12.
Dong C, Urgaonkar S, Cortese J, Gamo F, Garcia-Bustos J, LaFuente M, et al.
Chem Biol
. 2011 Dec;
18(12):1602-10.
PMID: 22195562
Here we report the discovery of tetracyclic benzothiazepines (BTZs) as highly potent and selective antimalarials along with the identification of the Plasmodium falciparum cytochrome bc(1) complex as the primary functional...
13.
Barker Jr R, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese J, et al.
Antimicrob Agents Chemother
. 2011 Mar;
55(6):2612-22.
PMID: 21422215
This study characterizes aminoindole molecules that are analogs of Genz-644442. Genz-644442 was identified as a hit in a screen of ~70,000 compounds in the Broad Institute's small-molecule library and the...
14.
Comeaux C, Coleman B, Bei A, Whitehurst N, Duraisingh M
Mol Microbiol
. 2011 Feb;
80(2):378-90.
PMID: 21320181
The Plasmodium RhopH complex is a high molecular weight antigenic complex consisting of three subunits - RhopH1/clag, RhopH2 and RhopH3 - located in the rhoptry secretory organelles of the invasive...
15.
Dvorin J, Bei A, Coleman B, Duraisingh M
Mol Microbiol
. 2010 May;
75(4):990-1006.
PMID: 20487292
The pathogenesis of Plasmodium falciparum depends on efficient invasion into host erythrocytes. Parasite ligands encoded by multi-gene families interact with erythrocyte receptors. P. falciparum reticulocyte binding protein homologues (PfRhs) are...
16.
Artavanis-Tsakonas K, Weihofen W, Antos J, Coleman B, Comeaux C, Duraisingh M, et al.
J Biol Chem
. 2010 Jan;
285(9):6857-66.
PMID: 20042598
Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. We previously identified PfUCHL3, a deubiquitinating enzyme, and here we characterize its activity and changes in...
17.
DeSimone T, Jennings C, Bei A, Comeaux C, Coleman B, Refour P, et al.
Mol Microbiol
. 2009 Apr;
72(3):578-89.
PMID: 19400777
Plasmodium falciparum is the most virulent of the Plasmodium species infective to humans. Different P. falciparum strains vary in their dependence on erythrocyte receptors for invasion and their ability to...
18.
Coleman B, Duraisingh M
Cell Microbiol
. 2008 Jul;
10(10):1935-46.
PMID: 18637022
Infection with the apicomplexan parasite Plasmodium falciparum is associated with a high burden of morbidity and mortality across the developing world, yet the mechanisms of transcriptional control in this organism...
19.
Blakesley R, Hansen N, Mullikin J, Thomas P, McDowell J, Maskeri B, et al.
Genome Res
. 2004 Oct;
14(11):2235-44.
PMID: 15479945
Although the cost of generating draft-quality genomic sequence continues to decline, refining that sequence by the process of "sequence finishing" remains expensive. Near-perfect finished sequence is an appropriate goal for...