Boris Adryan
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Explore the profile of Boris Adryan including associated specialties, affiliations and a list of published articles.
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42
Citations
2427
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Recent Articles
1.
Ma X, Ezer D, Adryan B, Stevens T
Genome Biol
. 2018 Oct;
19(1):174.
PMID: 30359306
Background: Transcription factor (TF) binding to regulatory DNA sites is a key determinant of cell identity within multi-cellular organisms and has been studied extensively in relation to site affinity and...
2.
Ezer D, Moignard V, Gottgens B, Adryan B
PLoS Comput Biol
. 2016 Aug;
12(8):e1005072.
PMID: 27551778
Many genes are expressed in bursts, which can contribute to cell-to-cell heterogeneity. It is now possible to measure this heterogeneity with high throughput single cell gene expression assays (single cell...
3.
Hosono C, Matsuda R, Adryan B, Samakovlis C
Nat Cell Biol
. 2015 Nov;
17(12):1569-76.
PMID: 26551273
In contrast to planes, three-dimensional (3D) structures such as tubes are physically anisotropic. Tubular organs exhibit a striking orientation of landmarks according to the physical anisotropy of the 3D shape,...
4.
Ma X, Ezer D, Navarro C, Adryan B
BMC Bioinformatics
. 2015 Aug;
16:265.
PMID: 26289072
Background: Scoring DNA sequences against Position Weight Matrices (PWMs) is a widely adopted method to identify putative transcription factor binding sites. While common bioinformatics tools produce scores that can reflect...
5.
Skalska L, Stojnic R, Li J, Fischer B, Cerda-Moya G, Sakai H, et al.
EMBO J
. 2015 Jun;
34(14):1889-904.
PMID: 26069324
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target selection and gene activation in each context. To investigate the influence of chromatin...
6.
Zabet N, Adryan B
Nucleic Acids Res
. 2014 Nov;
43(1):84-94.
PMID: 25432957
The binding of transcription factors (TFs) is essential for gene expression. One important characteristic is the actual occupancy of a putative binding site in the genome. In this study, we...
7.
Ezer D, Zabet N, Adryan B
Comput Struct Biotechnol J
. 2014 Oct;
10(17):63-9.
PMID: 25349675
The organization of binding sites in cis-regulatory elements (CREs) can influence gene expression through a combination of physical mechanisms, ranging from direct interactions between TF molecules to DNA looping and...
8.
Torella R, Li J, Kinrade E, Cerda-Moya G, Contreras A, Foy R, et al.
Nucleic Acids Res
. 2014 Aug;
42(16):10550-63.
PMID: 25114055
Regulation of transcription is fundamental to development and physiology, and occurs through binding of transcription factors to specific DNA sequences in the genome. CSL (CBF1/Suppressor of Hairless/LAG-1), a core component...
9.
Lin C, Dammai V, Adryan B, Hsu T
Naunyn Schmiedebergs Arch Pharmacol
. 2014 Jun;
388(2):143-52.
PMID: 24915993
Among the anti-tumor genes (tumor suppressors and metastasis suppressors), the von-Hippel Lindau gene and the Nm23 family of genes are among the more intriguing ones. Both are small (long and...
10.
Ezer D, Zabet N, Adryan B
Nucleic Acids Res
. 2014 Jan;
42(7):4196-207.
PMID: 24476912
Site-specific transcription factors (TFs) bind to their target sites on the DNA, where they regulate the rate at which genes are transcribed. Bacterial TFs undergo facilitated diffusion (a combination of...