Bjorn Onfelt
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Explore the profile of Bjorn Onfelt including associated specialties, affiliations and a list of published articles.
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68
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2183
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Recent Articles
11.
Sarhan D, Eisinger S, He F, Bergsland M, Pelicano C, Driescher C, et al.
iScience
. 2022 Oct;
25(11):105317.
PMID: 36310582
Immunotherapy for cancer that aims to promote T cell anti-tumor activity has changed current clinical practice, where some previously lethal cancers have now become treatable. However, clinical trials with low...
12.
Sandstrom N, Carannante V, Olofsson K, Sandoz P, Moussaud-Lamodiere E, Seashore-Ludlow B, et al.
Cell Rep Methods
. 2022 Jul;
2(7):100256.
PMID: 35880015
Here, we present a methodology based on multiplexed fluorescence screening of two- or three-dimensional cell cultures in a newly designed multichambered microwell chip, allowing direct assessment of drug or immune...
13.
Tay A, Prieto-Diaz R, Neo S, Tong L, Chen X, Carannante V, et al.
J Immunother Cancer
. 2022 May;
10(5).
PMID: 35580926
Background: Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, AARs. While blockade of the...
14.
Sandstrom N, Brandt L, Sandoz P, Zambarda C, Guldevall K, Schulz-Ruhtenberg M, et al.
Lab Chip
. 2022 Apr;
22(11):2107-2121.
PMID: 35470832
Miniaturization of cell culture substrates enables controlled analysis of living cells in confined micro-scale environments. This is particularly suitable for imaging individual cells over time, as they can be monitored...
15.
Arruda L, Stikvoort A, Lambert M, Jin L, Rivera L, Alves R, et al.
Haematologica
. 2022 Feb;
107(8):1786-1795.
PMID: 35142149
Less than a third of patients with acute myeloid leukemia (AML) are cured by chemotherapy and/or hematopoietic stem cell transplantation, highlighting the need to develop more efficient drugs. The low...
16.
Tuomela K, Mukherjee D, Ambrose A, Harikrishnan A, Mole H, Hurlstone A, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(3).
PMID: 35042775
The impact of radiotherapy on the interaction between immune cells and cancer cells is important not least because radiotherapy can be used alongside immunotherapy as a cancer treatment. Unexpectedly, we...
17.
Olofsson K, Carannante V, Takai M, Onfelt B, Wiklund M
Sci Rep
. 2021 Aug;
11(1):17076.
PMID: 34426602
Multicellular tumor spheroids (MCTSs) can serve as in vitro models for solid tumors and have become widely used in basic cancer research and drug screening applications. The major challenges when...
18.
Verron Q, Forslund E, Brandt L, Leino M, Frisk T, Olofsson P, et al.
Sci Signal
. 2021 May;
14(684).
PMID: 34035142
Immune synapses are large-scale, transient molecular assemblies that serve as platforms for antigen presentation to B and T cells and for target recognition by cytotoxic T cells and natural killer...
19.
Olofsson K, Carannante V, Takai M, Onfelt B, Wiklund M
Micromachines (Basel)
. 2021 Apr;
12(3).
PMID: 33804708
In cancer research and drug screening, multicellular tumor spheroids (MCTSs) are a popular model to bridge the gap between in vitro and in vivo. However, the current techniques to culture...
20.
Karampatzakis A, Broz P, Rey C, Onfelt B, Cruz De Matos G, Rycroft D, et al.
Front Immunol
. 2021 Apr;
12:641521.
PMID: 33796107
One mechanism by which monoclonal antibodies (mAb) help treat cancer or autoimmune disease is through triggering antibody-dependent cellular cytotoxicity (ADCC) CD16 on Natural Killer (NK) cells. Afucosylation is known to...