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Bi-Han Wu

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Recent Articles
1.
Wang J, Zhou Y, Wu B, Chen X, Zhai J, Tan J, et al.
Analyst . 2023 May; 148(10):2343-2351. PMID: 37185609
Helicases are crucial enzymes in DNA and RNA metabolism and function by unwinding particular nucleic acid structures. However, most convenient and high-throughput helicase assays are limited to the typical duplex...
2.
Tu J, Wu B, Wu H, Wang J, Zhang Z, Gao K, et al.
Eur J Med Chem . 2022 Dec; 246:114944. PMID: 36459756
The homologous recombination repair (HRR) pathway is critical for repairing double-strand breaks (DSB). Inhibition of the HRR pathway is usually considered a promising strategy for anticancer therapy. The Bloom's Syndrome...
3.
Li M, Yuan J, Yuan H, Wu B, Huang S, Li Q, et al.
J Med Chem . 2022 Sep; 65(19):12675-12700. PMID: 36121464
is a key driver of tumorigenesis. Repressing the transcription of by stabilizing the G-quadruplex (G4) structure with small molecules is a potential strategy for cancer therapy. Herein, we designed and...
4.
Zhao Y, Wu B, Liu Z, Qiao J, Zhao G
J Agric Food Chem . 2018 Nov; 66(51):13444-13453. PMID: 30488696
Resveratrol, a plant-derived polyphenolic compound with various health activities, is widely used in nutraceutical and food additives. Herein, combinatorial optimization of resveratrol biosynthetic pathway and intracellular environment of E. coli...