Bettina Winckler
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Explore the profile of Bettina Winckler including associated specialties, affiliations and a list of published articles.
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60
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1211
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Recent Articles
1.
Mulligan R, Magaj M, Digilio L, Redemann S, Yap C, Winckler B
J Cell Sci
. 2024 Apr;
137(9).
PMID: 38578235
Endosomal-lysosomal trafficking is accompanied by the acidification of endosomal compartments by the H+-V-ATPase to reach low lysosomal pH. Disruption of the correct pH impairs lysosomal function and the balance of...
2.
Mulligan R, Winckler B
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759799
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis....
3.
Yap C, Digilio L, McMahon L, Winckler B
J Biol Chem
. 2023 Jun;
299(7):104916.
PMID: 37315786
In neurons, degradation of dendritic cargos requires RAB7 and dynein-mediated retrograde transport to somatic lysosomes. To test if the dynein adapter RAB-interacting lysosomal protein (RILP) mediated the recruitment of dynein...
4.
Digilio L, McMahon L, Duston A, Yap C, Winckler B
Bio Protoc
. 2023 May;
13(10):e4675.
PMID: 37251096
Live imaging is commonly used to study dynamic processes in cells. Many labs carrying out live imaging in neurons use kymographs as a tool. Kymographs display time-dependent microscope data (time-lapsed...
5.
Yap C, Winckler B
Autophagy Rep
. 2023 Mar;
1(1):570-575.
PMID: 36969095
Dendrites differ from axons in multiple ways, including the presence of minus-end out microtubules intermixed with the more conventional plus-end out microtubules. The mixed microtubule polarity makes regulation of directional...
6.
Yap C, Digilio L, McMahon L, Winckler B
bioRxiv
. 2023 Mar;
PMID: 36945482
In neurons, degradation of dendritic cargos requires RAB7 and dynein-mediated retrograde transport to somatic lysosomes. In order to test if the dynein adaptor RILP (RAB-interacting lysosomal protein) mediated the recruitment...
7.
Mason A, Deppmann C, Winckler B
Neuroscientist
. 2023 Mar;
30(2):199-213.
PMID: 36942881
Extracellular vesicles (EVs) are secreted from most, if not all, cell types and are implicated in short- and long-distance signaling throughout the body. EVs are also secreted from neurons and...
8.
Mason A, Keeler A, Kabir F, Winckler B, Deppmann C
Sci Rep
. 2023 Mar;
13(1):3657.
PMID: 36871060
Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on...
9.
Mulligan R, Yap C, Winckler B
Methods Mol Biol
. 2022 Dec;
2557:595-618.
PMID: 36512240
High-level microscopy enables the comprehensive study of dynamic intracellular processes. Here we describe a toolkit of combinatorial approaches for fixed cell imaging and live cell imaging to investigate the interactions...
10.
Yap C, Digilio L, McMahon L, Wang T, Winckler B
J Neurosci
. 2022 Apr;
42(22):4415-4434.
PMID: 35474277
In all cell types, endocytosed cargo is transported along a set of endosomal compartments, which are linked maturationally from early endosomes (EEs) via late endosomes (LEs) to lysosomes. Lysosomes are...