Bettina Winckler
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Explore the profile of Bettina Winckler including associated specialties, affiliations and a list of published articles.
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60
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1211
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Recent Articles
11.
Yap C, Mason A, Winckler B
Curr Opin Neurobiol
. 2022 Apr;
74:102537.
PMID: 35398663
All cells are filled with membrane-bound organelles which are responsible for the synthesis and transport as well as degradation of membrane proteins. The localization of these organelles inside cells is...
12.
Yap C, Winckler B
Dev Biol
. 2022 Mar;
486:5-14.
PMID: 35306006
Many membrane proteins are highly enriched in either dendrites or axons. This non-uniform distribution is a critical feature of neuronal polarity and underlies neuronal function. The molecular mechanisms responsible for...
13.
Yap C, Winckler B
Dev Cell
. 2021 May;
56(10):1361-1362.
PMID: 34004149
Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. Roney et al. report that immature autophagosomes accumulate in axons...
14.
Bott C, McMahon L, Keil J, Yap C, Kwan K, Winckler B
J Neurosci
. 2020 Apr;
40(19):3720-3740.
PMID: 32273484
Nestin, an intermediate filament protein widely used as a marker of neural progenitors, was recently found to be expressed transiently in developing cortical neurons in culture and in developing mouse...
15.
Bott C, Winckler B
Cytoskeleton (Hoboken)
. 2020 Jan;
77(3-4):110-128.
PMID: 31970897
Neuronal development relies on a highly choreographed progression of dynamic cellular processes by which newborn neurons migrate, extend axons and dendrites, innervate their targets, and make functional synapses. Many of...
16.
Yong Y, Gamage K, Cheng I, Barford K, Spano A, Winckler B, et al.
J Neurosci
. 2019 Oct;
39(48):9503-9520.
PMID: 31628183
The regressive events associated with trophic deprivation are critical for sculpting a functional nervous system. After nerve growth factor withdrawal, sympathetic axons derived from male and female neonatal mice maintain...
17.
Chander P, Kennedy M, Winckler B, Weick J
eNeuro
. 2019 Jan;
6(1).
PMID: 30680309
Neurons have evolved a number of unique protein-coding genes that regulate trafficking of protein complexes within small organelles throughout dendrites and axons. Neuron-specific gene 2 (NSG2) encodes for one of...
18.
Winckler B, Faundez V, Maday S, Cai Q, Guimas Almeida C, Zhang H
J Neurosci
. 2018 Nov;
38(44):9364-9374.
PMID: 30381428
How do neurons adapt their endolysosomal system to address the particular challenge of membrane transport across their elaborate cellular landscape and to maintain proteostasis for the lifetime of the organism?...
19.
Yap C, Digilio L, Kruczek K, Roszkowska M, Fu X, Liu J, et al.
J Biol Chem
. 2018 Oct;
293(49):18890-18902.
PMID: 30291144
Doublecortin (DCX) is a protein needed for cortical development, and mutations cause cortical malformations in humans. The microtubule-binding activity of DCX is well-described and is important for its function, such...
20.
Yap C, Digilio L, McMahon L, Garcia A, Winckler B
J Cell Biol
. 2018 Jun;
217(9):3141-3159.
PMID: 29907658
Neurons are large and long lived, creating high needs for regulating protein turnover. Disturbances in proteostasis lead to aggregates and cellular stress. We characterized the behavior of the short-lived dendritic...