Bert L H Beerkens
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Explore the profile of Bert L H Beerkens including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
47
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0
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Recent Articles
1.
Beerkens B, IJzerman A, Heitman L, van der Es D
RSC Chem Biol
. 2025 Feb;
PMID: 39957994
Roughly one-third of all marketed drugs act by binding to one or more of the >800 human GPCRs, primarily through activation or inhibition the orthosteric binding site. In addition, novel...
2.
den Hollander L, Beerkens B, Dekkers S, Veldhoven J, Ortiz Zacarias N, van der Horst C, et al.
ACS Chem Biol
. 2024 Aug;
19(9):2070-2080.
PMID: 39186040
Interest in affinity-based probes (AfBPs) as novel tools to interrogate G protein-coupled receptors (GPCRs) has gained traction in recent years. AfBPs represent an interesting and more versatile alternative to antibodies....
3.
Beerkens B, Andrianopoulou V, Wang X, Liu R, van Westen G, Jespers W, et al.
ACS Chem Biol
. 2024 Jun;
19(7):1554-1562.
PMID: 38920052
Small molecular tool compounds play an essential role in the study of G protein-coupled receptors (GPCRs). However, tool compounds most often occupy the orthosteric binding site, hampering the study of...
4.
Beerkens B, Snijders I, Snoeck J, Liu R, Tool A, Le Devedec S, et al.
J Med Chem
. 2023 Aug;
66(16):11399-11413.
PMID: 37531576
The adenosine A receptor (AAR) is a G protein-coupled receptor (GPCR) that exerts immunomodulatory effects in pathophysiological conditions such as inflammation and cancer. Thus far, studies toward the downstream effects...
5.
Beerkens B, Koc C, Liu R, Florea B, Le Devedec S, Heitman L, et al.
ACS Chem Biol
. 2022 Oct;
17(11):3131-3139.
PMID: 36279267
G protein-coupled receptors (GPCRs) have been known for decades as attractive drug targets. This has led to the development and approval of many ligands targeting GPCRs. Although ligand binding effects...
6.
Beerkens B, Wang X, Avgeropoulou M, Adistia L, Veldhoven J, Jespers W, et al.
RSC Med Chem
. 2022 Aug;
13(7):850-856.
PMID: 35923720
Signalling through the adenosine receptors (ARs), in particular through the adenosine A receptor (AAR), has been shown to play a role in a variety of pathological conditions, ranging from immune...
7.
Bach K, Beerkens B, Zanon P, Hacker S
ACS Cent Sci
. 2020 Apr;
6(4):546-554.
PMID: 32342004
Covalent inhibitors have recently seen a resurgence of interest in drug development. Nevertheless, compounds, which do not rely on an enzymatic activity, have almost exclusively been developed to target cysteines....