Bernhard Laggerbauer
Overview
Explore the profile of Bernhard Laggerbauer including associated specialties, affiliations and a list of published articles.
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16
Citations
917
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Recent Articles
1.
Laggerbauer B, Engelhardt S
J Clin Invest
. 2022 Jun;
132(11).
PMID: 35642640
The discovery of microRNAs and their role in diseases was a breakthrough that inspired research into microRNAs as drug targets. Cardiovascular diseases are an area in which limitations of conventional...
2.
Sassi Y, Avramopoulos P, Ramanujam D, Gruter L, Werfel S, Giosele S, et al.
Nat Commun
. 2017 Nov;
8(1):1614.
PMID: 29158499
Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The microRNA-29 (miR-29) family has been found to prevent excess collagen expression in various organs, particularly through its function...
3.
Ramanujam D, Sassi Y, Laggerbauer B, Engelhardt S
Mol Ther
. 2016 Aug;
24(11):1939-1948.
PMID: 27545313
Systemic inhibition of miR-21 has proven effective against myocardial fibrosis and dysfunction, while studies in cardiac myocytes suggested a protective role in this cell type. Considering potential implications for therapy,...
4.
Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, et al.
J Mol Cell Cardiol
. 2016 Aug;
99:57-64.
PMID: 27539859
A key response of the myocardium to stress is the secretion of factors with paracrine or endocrine function. Intriguing in this respect is peptidase inhibitor 16 (PI16), a member of...
5.
Sassi Y, Ahles A, Truong D, Baqi Y, Lee S, Husse B, et al.
J Clin Invest
. 2014 Nov;
124(12):5385-97.
PMID: 25401477
Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained β-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure. Here, we have...
6.
Linder B, Hirmer A, Gal A, Ruther K, Bolz H, Winkler C, et al.
PLoS One
. 2014 Nov;
9(11):e111754.
PMID: 25383878
Pre-mRNA splicing by the spliceosome is an essential step in the maturation of nearly all human mRNAs. Mutations in six spliceosomal proteins, PRPF3, PRPF4, PRPF6, PRPF8, PRPF31 and SNRNP200, cause...
7.
Rinck A, Preusse M, Laggerbauer B, Lickert H, Engelhardt S, Theis F
RNA Biol
. 2013 May;
10(7):1125-35.
PMID: 23696004
MiRNAs are short, non-coding RNAs that regulate gene expression post-transcriptionally through specific binding to mRNA. Deregulation of miRNAs is associated with various diseases and interference with miRNA function has proven...
8.
Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, et al.
Circulation
. 2013 Apr;
127(21):2097-106.
PMID: 23625957
Background: Several microRNAs (miRs) have been shown to regulate gene expression in the heart, and dysregulation of their expression has been linked to cardiac disease. miR-378 is strongly expressed in...
9.
Hulot J, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, et al.
Circulation
. 2011 Aug;
124(7):796-805.
PMID: 21810664
Background: Cardiomyocytes use Ca2+ not only in excitation-contraction coupling but also as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear how Ca2+ triggers signaling in cardiomyocytes...
10.
Jentzsch C, Leierseder S, Loyer X, Flohrschutz I, Sassi Y, Hartmann D, et al.
J Mol Cell Cardiol
. 2011 Aug;
52(1):13-20.
PMID: 21801730
MicroRNAs (miRNAs) are small non-coding RNAs that control expression of complementary target mRNAs. A growing number of miRNAs has been implicated in the pathogenesis of cardiac diseases, mostly based not...