Bernard Ribalet
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Explore the profile of Bernard Ribalet including associated specialties, affiliations and a list of published articles.
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24
Citations
693
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Recent Articles
1.
John S, Calmettes G, Xu S, Ribalet B
PLoS One
. 2024 Mar;
19(3):e0300150.
PMID: 38457438
During hypoxia accumulation of lactate may be a key factor in acidosis-induced tissue damage. Binding of hexokinase (HK) to the outer membrane of mitochondria may have a protective effect under...
2.
John S, Calmettes G, Xu S, Ribalet B
PLoS One
. 2023 Nov;
18(11):e0286660.
PMID: 37917627
Lactate is a mitochondrial substrate for many tissues including neuron, muscle, skeletal and cardiac, as well as many cancer cells, however little is known about the processes that regulate its...
3.
Zhong M, Kawaguchi R, Costabile B, Tang Y, Hu J, Cheng G, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(18):9857-9864.
PMID: 32300017
Vitamin A has diverse biological functions and is essential for human survival at every point from embryogenesis to adulthood. Vitamin A and its derivatives have been used to treat human...
4.
Ghezzi C, Wong A, Chen B, Ribalet B, Damoiseaux R, Clark P
Nat Commun
. 2019 Dec;
10(1):5444.
PMID: 31784510
Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung...
5.
Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, et al.
Elife
. 2017 Dec;
6.
PMID: 29231167
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose...
6.
Ghezzi C, Calmettes G, Morand P, Ribalet B, John S
Physiol Rep
. 2017 Feb;
5(3).
PMID: 28193781
The processes controlling targeting of glucose transporters to apical and basolateral membranes of polarized cells are complex and not-well understood. We have engineered SGLT1 and GLUT4 constructs linked to fluorescent...
7.
Calmettes G, Ribalet B, John S, Korge P, Ping P, Weiss J
J Mol Cell Cardiol
. 2014 Sep;
78:107-15.
PMID: 25264175
As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione...
8.
Kim K, Srikanth S, Tan Y, Yee M, Jew M, Damoiseaux R, et al.
J Immunol
. 2013 Dec;
192(1):110-22.
PMID: 24307733
Orai1 is the pore subunit of Ca(2+) release-activated Ca(2+) (CRAC) channels that stimulate downstream signaling pathways crucial for T cell activation. CRAC channels are an attractive therapeutic target for alleviation...
9.
Calmettes G, John S, Weiss J, Ribalet B
J Gen Physiol
. 2013 Oct;
142(4):425-36.
PMID: 24081983
In mammalian tumor cell lines, localization of hexokinase (HK) isoforms to the cytoplasm or mitochondria has been shown to control their anabolic (glycogen synthesis) and catabolic (glycolysis) activities. In this...
10.
Srikanth S, Ribalet B, Gwack Y
Channels (Austin)
. 2013 Mar;
7(5):354-63.
PMID: 23454861
Store-operated Ca(2+) entry (SOCE) is a widespread mechanism to elevate the intracellular Ca(2+) concentrations and stimulate downstream signaling pathways affecting proliferation, secretion, differentiation and death in different cell types. In...