Sonal Srikanth
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Explore the profile of Sonal Srikanth including associated specialties, affiliations and a list of published articles.
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51
Citations
3997
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Recent Articles
1.
Wu B, Woo J, Hasiakos S, Pan C, Cokus S, Beninca C, et al.
Cell Rep
. 2025 Mar;
44(3):115430.
PMID: 40088449
Genetic and environmental factors shape an individual's susceptibility to autoimmunity. To identify genetic variations regulating effector T cell functions, we used a forward genetics screen of inbred mouse strains and...
2.
Nguyen A, Sung Y, Lee S, Martin C, Srikanth S, Chen W, et al.
Cells
. 2023 Sep;
12(18).
PMID: 37759448
Emerging evidence indicates that intracellular calcium (Ca) levels and their regulatory proteins play essential roles in normal stem cell proliferation and differentiation. Cancer stem-like cells (CSCs) are subpopulations of cancer...
3.
Howard E, Hurrell B, Helou D, Shafiei-Jahani P, Hasiakos S, Painter J, et al.
Nat Commun
. 2023 Sep;
14(1):5989.
PMID: 37752127
Ca entry via Ca release-activated Ca (CRAC) channels is a predominant mechanism of intracellular Ca elevation in immune cells. Here we show the immunoregulatory role of CRAC channel components Orai1...
4.
Jeyachandran A, Irudayam J, Dubey S, Chakravarty N, Konda B, Shah A, et al.
bioRxiv
. 2023 Aug;
PMID: 37577539
Background: Hantaviruses - dichotomized into New World (i.e. Andes virus, ANDV; Sin Nombre virus, SNV) and Old-World viruses (i.e. Hantaan virus, HTNV) - are zoonotic viruses transmitted from rodents to...
5.
Wu B, Woo J, Sun Z, Srikanth S, Gwack Y
J Immunol
. 2022 Feb;
208(6):1329-1340.
PMID: 35217583
Activation of the Ca release-activated Ca (CRAC) channel is crucial for T cell functions. It was recently shown that naked cuticle homolog 2 (NKD2), a signaling adaptor molecule, orchestrates trafficking...
6.
Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, et al.
Elife
. 2021 Dec;
10.
PMID: 34908525
CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and...
7.
Wu B, Ramaiah A, Garcia Jr G, Hasiakos S, Arumugaswami V, Srikanth S
J Immunol
. 2021 Nov;
208(1):74-84.
PMID: 34819389
ORAI1 and stromal interaction molecule 1 (STIM1) are the critical mediators of store-operated Ca entry by acting as the pore subunit and an endoplasmic reticulum-resident signaling molecule, respectively. In addition...
8.
Wu B, Woo J, Vila P, Jew M, Leung J, Sun Z, et al.
Cell Rep
. 2021 Aug;
36(8):109603.
PMID: 34433025
Sustained activation of the Ca-release-activated Ca (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of...
9.
ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling
Wu B, Ramaiah A, Garcia Jr G, Gwack Y, Arumugaswami V, Srikanth S
bioRxiv
. 2021 May;
PMID: 33972946
ORAI1 and STIM1 are the critical mediators of store-operated Ca entry by acting as the pore subunit and an endoplasmic reticulum-resident signaling molecule, respectively. In addition to Ca signaling, STIM1...
10.
Srikanth S, Gwack Y
Cell Calcium
. 2021 Feb;
95:102371.
PMID: 33626404
The current optogenetic tools to elevate cytoplasmic Ca concentrations either do not have high ion selectivity or activate undesirable signaling pathways. He et al. (2021) generated a light-operated Ca channel...