John J Mekalanos
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Explore the profile of John J Mekalanos including associated specialties, affiliations and a list of published articles.
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148
Citations
12031
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Recent Articles
1.
Robins W, Meader B, Toska J, Mekalanos J
Cell Rep
. 2024 Jul;
43(7):114450.
PMID: 39002129
Defense systems that recognize viruses provide important insights into both prokaryotic and eukaryotic innate immunity mechanisms. Such systems that restrict foreign DNA or trigger cell death have recently been recognized,...
2.
Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, et al.
Cell
. 2024 Jan;
187(4):897-913.e18.
PMID: 38280374
Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces....
3.
Ahmed S, Oliva G, Shao M, Mekalanos J, Brenner G
Hum Vaccin Immunother
. 2023 Oct;
19(2):2262639.
PMID: 37786375
Schwannomas are slow-growing benign peripheral nerve sheath tumors derived from Schwann-lineage cells that develop in association with NF2-related schwannomatosis (NF2) and schwannomatosis (NF3), as well as spontaneously. Individuals affected with...
4.
Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, et al.
bioRxiv
. 2023 Feb;
PMID: 36778396
Highlights: Gut complement component 3 (C3) is induced by the microbiome in healthy humans and mice at a microbiota-specific level.Gut stromal cells located in intestinal lymphoid follicles are a major...
5.
Pons S, Frapy E, Sereme Y, Gaultier C, Lebreton F, Kropec A, et al.
EBioMedicine
. 2023 Jan;
88:104439.
PMID: 36709579
Background: Worldwide, Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but full understanding of the pathogenesis of this disease is not yet achieved. Moreover, to date, no...
6.
LaPorte J, Spinard E, Cavanagh D, Gomez-Chiarri M, Rowley D, Mekalanos J, et al.
Microbiol Resour Announc
. 2023 Jan;
12(2):e0087322.
PMID: 36656017
Here, we announce the draft genome sequence of Vibrio parahaemolyticus strain PSU5579, isolated from a shrimp hatchery in southern Thailand during an outbreak of acute hepatopancreatic necrosis disease (AHPND). The...
7.
Chou S, Guo H, Zingl F, Zhang S, Toska J, Xu B, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2219679120.
PMID: 36649429
The emergence of multidrug-resistant bacterial pathogens is a growing threat to global public health. Here, we report the development and characterization of a panel of nine-amino acid residue synthetic peptides...
8.
Robins W, Mekalanos J
PLoS One
. 2022 Jul;
17(7):e0270276.
PMID: 35895734
SARS-CoV-2 is one of three recognized coronaviruses (CoVs) that have caused epidemics or pandemics in the 21st century and that likely emerged from animal reservoirs. Differences in nucleotide and protein...
9.
Ahmed S, Oliva G, Shao M, Wang X, Mekalanos J, Brenner G
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2202719119.
PMID: 35675425
Schwannomas are slow-growing benign neoplasms that develop throughout the body causing pain, sensory/motor dysfunction, and death. Because bacterial immunotherapy has been used in the treatment of some malignant neoplasms, we...
10.
Rivera-Chavez F, Meader B, Akosman S, Koprivica V, Mekalanos J
Toxins (Basel)
. 2022 Mar;
14(3).
PMID: 35324722
uses cholera toxin (CT) to cause cholera, a severe diarrheal disease in humans that can lead to death within hours of the onset of symptoms. The catalytic activity of CT...