Benjamin E Turk
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Explore the profile of Benjamin E Turk including associated specialties, affiliations and a list of published articles.
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118
Citations
6893
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Recent Articles
1.
Robles J, Stiegler A, Boggon T, Turk B
J Biol Chem
. 2025 Feb;
:108348.
PMID: 40015635
The protein kinase ERK2 is recurrently mutated in human squamous cell carcinomas and other tumors. ERK2 mutations cluster in an essential docking recruitment site that interacts with short linear motifs...
2.
McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, et al.
Cancer Immunol Res
. 2024 Nov;
13(2):245-257.
PMID: 39589394
Despite recent advances in the treatment of melanoma, many patients with metastatic disease still succumb to their disease. To identify tumor-intrinsic modulators of immunity to melanoma, we performed a whole-genome...
3.
Ballmer D, Lou H, Ishii M, Turk B, Akiyoshi B
J Cell Biol
. 2024 Aug;
223(11).
PMID: 39196069
Kinetochores form the interface between chromosomes and spindle microtubules and are thus under tight control by a complex regulatory circuitry. The Aurora B kinase plays a central role within this...
4.
Zhang H, Read A, Cataisson C, Yang H, Lee W, Turk B, et al.
Sci Signal
. 2024 May;
17(836):eadd5073.
PMID: 38743809
The Ras-mitogen-activated protein kinase (MAPK) pathway is a major target for cancer treatment. To better understand the genetic pathways that modulate cancer cell sensitivity to MAPK pathway inhibitors, we performed...
5.
Yaron-Barir T, Joughin B, Huntsman E, Kerelsky A, Cizin D, Cohen B, et al.
Nature
. 2024 May;
629(8014):1174-1181.
PMID: 38720073
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth. Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that...
6.
Sexton J, Potchernikov T, Bibeau J, Casanova-Sepulveda G, Cao W, Lou H, et al.
Nat Commun
. 2024 Feb;
15(1):1426.
PMID: 38365893
Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short, unstructured N-terminal region of cofilin is critical for actin binding and harbors...
7.
Ballmer D, Lou H, Ishii M, Turk B, Akiyoshi B
bioRxiv
. 2024 Jan;
PMID: 38293145
Accurate chromosome segregation during mitosis requires that all chromosomes establish stable bi-oriented attachments with the spindle apparatus. Kinetochores form the interface between chromosomes and spindle microtubules and as such are...
8.
Casanova-Sepulveda G, Sexton J, Turk B, Boggon T
Nat Commun
. 2023 Dec;
14(1):8441.
PMID: 38114480
LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament severing, and are key nodes between Rho...
9.
Robles J, Lou H, Shi G, Pan P, Turk B
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2316599120.
PMID: 37988460
Mitogen-activated protein kinase (MAPK) cascades are essential for eukaryotic cells to integrate and respond to diverse stimuli. Maintaining specificity in signaling through MAPK networks is key to coupling distinct inputs...
10.
Sexton J, Potchernikov T, Bibeau J, Casanova-Sepulveda G, Cao W, Lou H, et al.
bioRxiv
. 2023 Jul;
PMID: 37425676
Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short unstructured N-terminal region of cofilin is critical for actin binding and harbors...