Benjamin D Sellers
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Explore the profile of Benjamin D Sellers including associated specialties, affiliations and a list of published articles.
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28
Citations
591
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Recent Articles
1.
Sun D, Storek K, Tegunov D, Yang Y, Arthur C, Johnson M, et al.
Nat Commun
. 2024 Oct;
15(1):8718.
PMID: 39379361
BamA is the central component of the essential β-barrel assembly machine (BAM), a conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the outer membrane of Gram-negative bacteria....
2.
Lawson C, Kryshtafovych A, Pintilie G, Burley S, cerny J, Chen V, et al.
Nat Methods
. 2024 Jun;
21(7):1340-1348.
PMID: 38918604
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein-nucleic acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at...
3.
Lawson C, Kryshtafovych A, Pintilie G, Burley S, cerny J, Chen V, et al.
Res Sq
. 2024 Feb;
PMID: 38343795
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at near-atomic...
4.
Latham A, Levy E, Sellers B, Leung D
Pharmaceutics
. 2024 Jan;
16(1).
PMID: 38258061
Drug nanosuspensions offer a promising approach to improve bioavailability for poorly soluble drug candidates. Such formulations often necessitate the inclusion of an excipient to stabilize the drug nanoparticles. However, the...
5.
Aliagas I, Gobbi A, Lee M, Sellers B
J Comput Aided Mol Des
. 2022 Apr;
36(3):253-262.
PMID: 35359246
In drug discovery, partition and distribution coefficients, logP and logD for octanol/water, are widely used as metrics of the lipophilicity of molecules, which in turn have a strong influence on...
6.
Verma V, Wang L, Labadie S, Liang J, Sellers B, Wang J, et al.
J Med Chem
. 2022 Feb;
65(5):4085-4120.
PMID: 35184554
The dramatic increase in the prevalence of multi-drug resistant Gram-negative bacterial infections and the simultaneous lack of new classes of antibiotics is projected to result in approximately 10 million deaths...
7.
Wang S, Krummenacher K, Landrum G, Sellers B, Di Lello P, Robinson S, et al.
J Chem Inf Model
. 2022 Jan;
62(3):472-485.
PMID: 35029985
Nuclear magnetic resonance (NMR) data from NOESY (nuclear Overhauser enhancement spectroscopy) and ROESY (rotating frame Overhauser enhancement spectroscopy) experiments can easily be combined with distance geometry (DG) based conformer generators...
8.
Clairfeuille T, Buchholz K, Li Q, Verschueren E, Liu P, Sangaraju D, et al.
Nature
. 2020 Aug;
584(7821):479-483.
PMID: 32788728
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function. LPS can cause death as a result of septic shock, and its lipid...
9.
Parr B, Pastor R, Sellers B, Pei Z, Jaipuri F, Castanedo G, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):541-549.
PMID: 32292562
A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway modulation was demonstrated , which enabled...
10.
Ferrar J, Sellers B, Chan C, Leung D
Int J Pharm
. 2020 Feb;
578:119094.
PMID: 32006625
Suspensions of drug nanoparticles known as nanosuspensions have emerged as a successful enabling formulation approach for poorly soluble drug candidates. These nanoparticles typically require stabilization with specific polymer or surfactant...