Jesse E Hanson
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Explore the profile of Jesse E Hanson including associated specialties, affiliations and a list of published articles.
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47
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2328
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Recent Articles
1.
Boggess S, Gandhi V, Tsai M, Marzette E, Teyssier N, Yu-Ying Chou J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990495
Understanding the complex interplay between gene expression and neuronal activity is crucial for unraveling the molecular mechanisms underlying cognitive function and neurological disorders. Here, we developed pooled screens for neuronal...
2.
Rao S, Yung J, Edick M, Hanson J
STAR Protoc
. 2024 Oct;
5(4):103388.
PMID: 39418161
Complement proteins contribute to neurodegeneration in Alzheimer's disease (AD) and are secreted by glia surrounding beta-amyloid (Aβ) plaques. We present an optimized protocol for Aβ plaque detection with tyramide-digoxigenin signal...
3.
Sandoval C, Lee J, Toth B, Nagaraj R, Schauer S, Hoffman J, et al.
Alzheimers Dement
. 2024 Oct;
20(11):7940-7953.
PMID: 39369294
Introduction: Growing evidence suggests a role for neuroinflammation in Alzheimer's disease (AD). We investigated complement pathway activity in AD patient cerebrospinal fluid (CSF) and evaluated its modulation by the anti-tau...
4.
Lu Y, Mu L, Elstrott J, Fu C, Sun C, Su T, et al.
EBioMedicine
. 2024 Mar;
102:105045.
PMID: 38471394
Background: Schizophrenia, a debilitating psychiatric disorder, displays considerable interindividual variation in clinical presentations. The ongoing debate revolves around whether this heterogeneity signifies a continuum of severity linked to a singular...
5.
Dejanovic B, Sheng M, Hanson J
Nat Rev Drug Discov
. 2023 Nov;
23(1):23-42.
PMID: 38012296
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or reverse synaptic damage remain elusive. In this...
6.
Wang Y, Wu T, Tsai M, Rezzonico M, Abdel-Haleem A, Xie L, et al.
Elife
. 2023 Aug;
12.
PMID: 37555828
Tumor progression locus 2 (TPL2) (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and...
7.
Hanson J, Yuan H, Perszyk R, Banke T, Xing H, Tsai M, et al.
Neuropsychopharmacology
. 2023 Jun;
49(1):51-66.
PMID: 37369776
N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory synaptic transmission, are widely distributed throughout the central nervous system, and regulate synaptic plasticity. NMDA receptor modulators have long been considered...
8.
Wang Y, Weber M, Foreman O, Remy H, Mracsko E, Hanson J
Sci Transl Med
. 2023 May;
15(696):eade8728.
PMID: 37196063
We highlight potential issues with a Western blot assay using mouse anti-caspase-1 antibody to detect cleaved caspase-1 p20 subunit in mouse brain tissue lysates.
9.
Dejanovic B, Wu T, Tsai M, Graykowski D, Gandham V, Rose C, et al.
Nat Aging
. 2023 Apr;
2(9):837-850.
PMID: 37118504
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau synapse fractions with age...
10.
Zhou J, Wade S, Graykowski D, Xiao M, Zhao B, Giannini L, et al.
Sci Transl Med
. 2023 Mar;
15(689):eadf0141.
PMID: 36989373
Complement overactivation mediates microglial synapse elimination in neurological diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown....