Benedict C S Cross
Overview
Explore the profile of Benedict C S Cross including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
766
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0
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Recent Articles
1.
Bellail A, Jin H, Lo H, Jung S, Hamdouchi C, Kim D, et al.
Sci Transl Med
. 2021 Oct;
13(615):eabh1486.
PMID: 34644148
Discovery of small-molecule degraders that activate ubiquitin ligase–mediated ubiquitination and degradation of targeted oncoproteins in cancer cells has been an elusive therapeutic strategy. Here, we report a cancer cell–based drug...
2.
Blanck M, Budnik-Zawilska M, Lenger S, McGonigle J, Martin G, le Sage C, et al.
CRISPR J
. 2020 Oct;
3(3):211-222.
PMID: 33054419
Functional genomic screening with CRISPR has provided a powerful and precise new way to interrogate the phenotypic consequences of gene manipulation in high-throughput, unbiased analyses. However, some experimental paradigms prove...
3.
le Sage C, Lawo S, Cross B
SLAS Discov
. 2019 Oct;
25(3):233-240.
PMID: 31658850
The discovery of CRISPR-Cas9 systems has fueled a rapid expansion of gene editing adoption and has impacted pharmaceutical and biotechnology research substantially. Here, gene editing is used at an industrial...
4.
Cho J, Lee A, Platzer B, Cross B, Gardner B, De Luca H, et al.
Cell Host Microbe
. 2018 Apr;
23(4):571.
PMID: 29649448
No abstract available.
5.
le Sage C, Lawo S, Panicker P, Scales T, Rahman S, Little A, et al.
Sci Rep
. 2017 Dec;
7(1):17693.
PMID: 29255251
Pooled CRISPR-Cas9 knock out screens provide a valuable addition to the methods available for novel drug target identification and validation. However, where gene editing is targeted to amplified loci, the...
6.
Cross B, Lawo S, Archer C, Hunt J, Yarker J, Riccombeni A, et al.
Sci Rep
. 2016 Aug;
6:31782.
PMID: 27545104
Components of the type II CRISPR-Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic...
7.
Tomasio S, Harding H, Ron D, Cross B, Bond P
Mol Biosyst
. 2013 Jul;
9(10):2408-16.
PMID: 23884086
Constitutive protein misfolding in the endoplasmic reticulum (ER) can lead to cellular toxicity and disease. Consequently, the protein folding environment within the ER is highly optimised and tightly regulated by...
8.
Cho J, Lee A, Platzer B, Cross B, Gardner B, De Luca H, et al.
Cell Host Microbe
. 2013 May;
13(5):558-569.
PMID: 23684307
The plasma membrane and all membrane-bound organelles except for the Golgi and endoplasmic reticulum (ER) are equipped with pattern-recognition molecules to sense microbes or their products and induce innate immunity...
9.
Avezov E, Cross B, Kaminski Schierle G, Winters M, Harding H, Melo E, et al.
J Cell Biol
. 2013 Apr;
201(2):337-49.
PMID: 23589496
Interfering with disulfide bond formation impedes protein folding and promotes endoplasmic reticulum (ER) stress. Due to limitations in measurement techniques, the relationships of altered thiol redox and ER stress have...
10.
Ojemalm K, Watson H, Roboti P, Cross B, Warwicker J, von Heijne G, et al.
J Cell Sci
. 2012 Dec;
126(Pt 2):464-72.
PMID: 23230148
The integration of transmembrane (TM)-spanning regions of many channels and ion transporters is potentially compromised by the presence of polar and charged residues required for biological function. Although the two...