Benedetta Maggio

Overview

Explore the profile of Benedetta Maggio including associated specialties, affiliations and a list of published articles.

Snapshot

Articles 35

Citations 262

Followers 0

Related Specialties

Chemistry

Pharmacology

Biochemistry

Top 10 Co-Authors

Demetrio Raffa

Giuseppe Daidone

Maria Valeria Raimondi

Fabiana Plescia

Stella Cascioferro

Domenico Schillaci

Maria Grazia Cusimano

Salvatore Plescia

Marianna Lauricella

Manlio Tolomeo

Published In

Eur J Med Chem

Farmaco

Arch Pharm (Weinheim)

Acta Crystallogr Sect E Struct Rep Online

Molecules

Affiliations

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Recent Articles

11.

Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality

Raffa D, Maggio B, Plescia F, Cascioferro S, Raimondi M, Cancemi G, et al.

Bioorg Med Chem . 2015 Sep; 23(19):6305-16. PMID: 26344588

Several new 2-(2-phenoxyacetamido)benzamides 17a-v, 21 and 22 were synthesized by stirring in pyridine the acid chlorides 16a-e and the appropriate5-R-4-R₁-2-aminobenzamide 15a-e and initially evaluated in vitro for antiproliferative activity against...

12.

Sortase A Inhibitors: Recent Advances and Future Perspectives

Cascioferro S, Raffa D, Maggio B, Raimondi M, Schillaci D, Daidone G

J Med Chem . 2015 Aug; 58(23):9108-23. PMID: 26280844

Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as antivirulence drugs. Sortase A is...

13.

Synthesis and antiproliferative activity of 3-(2-chloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one

Maggio B, Raimondi M, Raffa D, Plescia F, Cascioferro S, Cancemi G, et al.

Eur J Med Chem . 2015 Apr; 96:98-104. PMID: 25874335

Based on the encouraging results found for 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one 7 previously tested by us, as well as the consideration that heterocycle fused tetrazepinones bearing the 2-chloroethyl substituent show a better cytotoxic...

14.

Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle

Raffa D, Maggio B, Raimondi M, Cascioferro S, Plescia F, Cancemi G, et al.

Eur J Med Chem . 2015 Jan; 97:732-46. PMID: 25549911

In this review we report the recent advances in bioactive system containing pyrazole fused with a five membered heterocycle, covering the time span of the last decade. All of them...

15.

Synthesis and antiproliferative activity of new derivatives containing the polycyclic system 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3',4':2,3]azepino[4,5-f]azocine

Maggio B, Raffa D, Raimondi M, Cusimano M, Plescia F, Cascioferro S, et al.

Eur J Med Chem . 2013 Dec; 72:1-9. PMID: 24333609

The reaction under reflux between 1-phenyl-3-R-5-methylaminopyrazoles and 2,5-hexanedione lead to 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3',4':2,3]azepino[4,5-f]azocine derivatives 3b-g. These unusual molecules show the structural complexity of many biologically active natural products and are endowed with...

16.

Non-classical transformation of benzendiazonium hydrogen sulfates. Access to 1,3-dimethylisochromeno[4,3-c]pyrazol-5(1H)-one, a potential benzodiazepine receptor ligand

Maggio B, Raffa D, Raimondi M, Daidone G

Molecules . 2013 Oct; 18(10):13096-110. PMID: 24152597

The compound 2-((1,3-dimethyl-1H-pyrazol-5-yl)(methyl)carbamoyl)benzene-diazonium hydrogen sulfate (10) was reacted with copper sulfate and sodium chloride, in the presence of ascorbic acid as reducing agent, to afford a mixture of the chlorinated...

17.

(E)-2-{[1-(3,11-Dimethyl-4-methyl-ene-10-oxo-1-phenyl-4,5,10,11-tetra-hydro-1H-benzo[b]pyrazolo-[3,4-f][1,5]diazo-cin-5-yl)ethyl-idene]amino}-N-methyl-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide

Meneghetti F, Maggio B

Acta Crystallogr Sect E Struct Rep Online . 2013 Oct; 69(Pt 10):o1583. PMID: 24098259

The central eight-membered ring of the title compound, C40H36N8O2, deviates from the ideal boat conformation because the bond between the exo-ethyl-ene group and the adjacent N atom is twisted by...

18.

N-(4-Acetyl-3-methyl-1-phenyl-1H-pyrazol-5-yl)-N-methyl-2-(2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzamide

Meneghetti F, Maggio B

Acta Crystallogr Sect E Struct Rep Online . 2013 Oct; 69(Pt 10):o1582. PMID: 24098258

In the title compound, C29H25N5O3, the dihedral angle between the benzene ring and the pendant quinazoline ring system (r.m.s. deviation = 0.036Å) is 87.60 (17)°. The equivalent angle between the...

19.

2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action

Raffa D, Maggio B, Raimondi M, Cusimano M, Amico G, Carollo A, et al.

Eur J Med Chem . 2013 Jun; 65:427-35. PMID: 23747810

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in...

20.

Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives

Raimondi M, Maggio B, Raffa D, Plescia F, Cascioferro S, Cancemi G, et al.

Eur J Med Chem . 2012 Oct; 58:64-71. PMID: 23088933

Several new 4-diazopyrazole derivatives 6a-g and 9a-c were obtained by the reaction of 1-(R-substituted-phenyl)-3-(1,3-dimethyl-1H-pyrazol-5-yl)ureas 5a-g and N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-(R-substituted-phenyl)acetamides 8a-c respectively with a sevenfold excess of nitrous acid in acetic acid solution....