Ben S Wittner
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Explore the profile of Ben S Wittner including associated specialties, affiliations and a list of published articles.
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46
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8517
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Recent Articles
11.
Hong X, Roh W, Sullivan R, Wong K, Wittner B, Guo H, et al.
Cancer Discov
. 2020 Nov;
11(3):678-695.
PMID: 33203734
Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from patients with melanoma...
12.
Ebright R, Lee S, Wittner B, Niederhoffer K, Nicholson B, Bardia A, et al.
Science
. 2020 Feb;
367(6485):1468-1473.
PMID: 32029688
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset of these cells generates metastases. We conducted an in vivo genome-wide CRISPR activation...
13.
Medford A, Dubash T, Juric D, Spring L, Niemierko A, Vidula N, et al.
NPJ Precis Oncol
. 2019 Jul;
3:18.
PMID: 31341951
Plasma genotyping identifies potentially actionable mutations at variable mutant allele frequencies, often admixed with multiple subclonal variants, highlighting the need for their clinical and functional validation. We prospectively monitored plasma...
14.
Zheng Y, Comaills V, Burr R, Boulay G, Miyamoto D, Wittner B, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(12):5223-5232.
PMID: 30819896
Tumor-stromal communication within the microenvironment contributes to initiation of metastasis and may present a therapeutic opportunity. Using serial single-cell RNA sequencing in an orthotopic mouse prostate cancer model, we find...
15.
Kwan T, Bardia A, Spring L, Giobbie-Hurder A, Kalinich M, Dubash T, et al.
Cancer Discov
. 2018 Aug;
8(10):1286-1299.
PMID: 30104333
The multiplicity of new therapies for breast cancer presents a challenge for treatment selection. We describe a 17-gene digital signature of breast circulating tumor cell (CTC)-derived transcripts enriched from blood,...
16.
Aceto N, Bardia A, Wittner B, Donaldson M, OKeefe R, Engstrom A, et al.
Mol Cancer Res
. 2018 Feb;
16(4):720-727.
PMID: 29453314
Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing was performed of circulating tumor cells...
17.
Hong X, Sullivan R, Kalinich M, Kwan T, Giobbie-Hurder A, Pan S, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(10):2467-2472.
PMID: 29453278
A subset of patients with metastatic melanoma have sustained remissions following treatment with immune checkpoint inhibitors. However, analyses of pretreatment tumor biopsies for markers predictive of response, including PD-1 ligand...
18.
Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer
Gallenne T, Ross K, Visser N, Salony , Desmet C, Wittner B, et al.
Oncotarget
. 2017 Apr;
8(13):20572-20587.
PMID: 28411283
Prognostic classifiers conceivably comprise biomarker genes that functionally contribute to the oncogenic and metastatic properties of cancer, but this has not been investigated systematically. The transcription factor Fra-1 not only...
19.
Zheng Y, Miyamoto D, Wittner B, Sullivan J, Aceto N, Vincent Jordan N, et al.
Nat Commun
. 2017 Feb;
8:14344.
PMID: 28181495
Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs from breast, prostate and...
20.
Vincent Jordan N, Bardia A, Wittner B, Benes C, Ligorio M, Zheng Y, et al.
Nature
. 2016 Aug;
537(7618):102-106.
PMID: 27556950
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified...