Beiling Chen
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Explore the profile of Beiling Chen including associated specialties, affiliations and a list of published articles.
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9
Citations
237
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Recent Articles
1.
Sheng D, Chen B, Wang C, Xiao X, Hu A, Liu W, et al.
Med Oncol
. 2022 Dec;
40(2):69.
PMID: 36586017
In cancer cells, multiple oncogenes and tumor suppressors control glycolysis to sustain rapid proliferation. The ETS-related transcription factor Fli1 plays a critical role in the induction and progression of leukemia,...
2.
Liu W, Gajendran B, Sample K, Wang C, Hu A, Chen B, et al.
Cancer Gene Ther
. 2022 Apr;
29(11):1590-1599.
PMID: 35477769
RAS oncogenes are major drivers of diverse types of cancer. However, they are largely not druggable, and therefore targeting critical downstream pathways and dependencies is an attractive approach. We have...
3.
Chen B, Sheng D, Wang C, Liu W, Hu A, Xiao X, et al.
Cell Signal
. 2022 Feb;
92:110269.
PMID: 35104574
Inflammation plays a critical role in cancer initiation and progression, and is induced by inflammatory factors that are direct target of oncogenes and tumor suppressors. The ETS related transcription factor...
4.
Tsui S, Fernando R, Chen B, Smith T
J Biol Chem
. 2011 May;
286(27):24487-99.
PMID: 21576248
UDP-glucose dehydrogenase (UGDH) catalyzes the formation of UDP-glucuronate. Glucuronate represents an integral component of the glycosaminoglycan, hyaluronan, which accumulates in orbital Graves disease. Here we report that orbital fibroblasts express...
5.
Hwang C, Afifiyan N, Sand D, Naik V, Said J, Pollock S, et al.
Invest Ophthalmol Vis Sci
. 2009 Jan;
50(5):2262-8.
PMID: 19117935
Purpose: Fibroblast diversity represents an emerging concept critical to our understanding of tissue inflammation, repair, and remodeling. Orbital fibroblasts heterogeneously display Thy-1 and exhibit unique phenotypic attributes that may explain...
6.
Smith T, Tsai C, Shih M, Tsui S, Chen B, Han R, et al.
Thyroid
. 2008 Sep;
18(9):983-8.
PMID: 18788919
Tissue remodeling associated with thyroid-associated ophthalmopathy (TAO) involves the complex interplay between resident cells (endothelium, vascular smooth muscle, extraocular muscle, and fibroblasts) and those recruited to the orbit, including members...
7.
Han R, Chen B, Smith T
J Immunol
. 2007 Nov;
179(10):7147-56.
PMID: 17982107
Prostaglandin endoperoxide H synthase 2 (PGHS-2) catalyzes the rate-limiting steps in the synthesis of PGE(2). It is substantially but transiently induced in human orbital fibroblasts treated with IL-1beta. In this...
8.
Chen B, Tsui S, Boeglin W, Douglas R, Brash A, Smith T
J Biol Chem
. 2006 May;
281(27):18296-306.
PMID: 16675443
Orbital fibroblasts orchestrate tissue remodeling in Graves disease, at least in part, because they exhibit exaggerated responses to proinflammatory cytokines. A hallmark of late stage orbital disease is vision-threatening fibrosis,...
9.
Chen B, Tsui S, Smith T
J Immunol
. 2005 Jul;
175(2):1310-9.
PMID: 16002736
Human orbital fibroblasts exhibit a unique inflammatory phenotype. In the present study, we report that these fibroblasts, when treated with IL-1beta, express high levels of IL-6, a cytokine involved in...