Klarke M Sample
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Explore the profile of Klarke M Sample including associated specialties, affiliations and a list of published articles.
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20
Citations
171
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Recent Articles
1.
Zheng L, Pan C, Tian W, Liang C, Feng Y, He W, et al.
Cell Oncol (Dordr)
. 2023 Mar;
46(4):1069-1083.
PMID: 36930333
Purpose: The eukaryotic cell plasma membrane contains several asymmetrically distributed phospholipids, which is maintained by the P4-ATPase flippase complex. Herein, we demonstrated the biological effects and mechanisms of asymmetrical loss...
2.
Qiu Q, Sun Y, Yang L, Li Q, Feng Y, Li M, et al.
Signal Transduct Target Ther
. 2023 Feb;
8(1):90.
PMID: 36854750
We report herein that TSPAN32 is a key node factor for Philadelphia (Ph) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib...
3.
Sheng D, Chen B, Wang C, Xiao X, Hu A, Liu W, et al.
Med Oncol
. 2022 Dec;
40(2):69.
PMID: 36586017
In cancer cells, multiple oncogenes and tumor suppressors control glycolysis to sustain rapid proliferation. The ETS-related transcription factor Fli1 plays a critical role in the induction and progression of leukemia,...
4.
Liu W, Gajendran B, Sample K, Wang C, Hu A, Chen B, et al.
Cancer Gene Ther
. 2022 Apr;
29(11):1590-1599.
PMID: 35477769
RAS oncogenes are major drivers of diverse types of cancer. However, they are largely not druggable, and therefore targeting critical downstream pathways and dependencies is an attractive approach. We have...
5.
Li N, Wang N, He W, Feng Y, Qiu Q, Qiu H, et al.
Int J Biol Sci
. 2022 Apr;
18(6):2277-2291.
PMID: 35414788
RORA plays an important role in regulating circadian rhythms, inflammation, metabolism and cellular development. Herein, we explore the roles of in B cell proliferation and differentiation, as well as in...
6.
Ben-David Y, Gajendran B, Sample K, Zacksenhaus E
Cell Mol Life Sci
. 2022 Apr;
79(3):163.
PMID: 35412146
Fli-1, a member of the ETS family of transcription factors, was discovered in 1991 through retroviral insertional mutagenesis as a driver of mouse erythroleukemias. In the past 30 years, nearly...
7.
Chen B, Sheng D, Wang C, Liu W, Hu A, Xiao X, et al.
Cell Signal
. 2022 Feb;
92:110269.
PMID: 35104574
Inflammation plays a critical role in cancer initiation and progression, and is induced by inflammatory factors that are direct target of oncogenes and tumor suppressors. The ETS related transcription factor...
8.
Gao Y, Zhou Y, Wang C, Sample K, Yu X, Ben-David Y
Oncol Rep
. 2021 Oct;
46(6).
PMID: 34617574
Propofol is a commonly used anesthetic with controversial effects on cancer cells. A growing number of studies have demonstrated that low concentrations of propofol are associated with tumor suppression and...
9.
Yu F, Gajendran B, Wang N, Sample K, Liu W, Wang C, et al.
BMC Cancer
. 2021 Jun;
21(1):680.
PMID: 34107900
Background: Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis,...
10.
Wang C, Sample K, Gajendran B, Kapranov P, Liu W, Hu A, et al.
Front Immunol
. 2021 Mar;
12:607836.
PMID: 33717090
Wiskott-Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the gene, which together with its homolog, N-, regulates actin cytoskeleton remodeling and cell motility. WAS patients...