Beeke Wienert
Overview
Explore the profile of Beeke Wienert including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
865
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Martyn G, Wienert B, Kurita R, Nakamura Y, Quinlan K, Crossley M
Blood
. 2019 Jan;
133(8):852-856.
PMID: 30617196
β-hemoglobinopathies, such as sickle cell disease and β-thalassemia, result from mutations in the adult gene. Reactivating the developmentally silenced fetal gene elevates fetal hemoglobin levels and ameliorates symptoms of β-hemoglobinopathies....
12.
Wienert B, Martyn G, Funnell A, Quinlan K, Crossley M
Trends Genet
. 2018 Oct;
34(12):927-940.
PMID: 30287096
Disorders in hemoglobin (hemoglobinopathies) were the first monogenic diseases to be characterized and remain among the most common and best understood genetic conditions. Moreover, the study of the β-globin locus...
13.
Wienert B, Shin J, Zelin E, Pestal K, Corn J
PLoS Biol
. 2018 Jul;
16(7):e2005840.
PMID: 30011268
Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell...
14.
Martyn G, Wienert B, Yang L, Shah M, Norton L, Burdach J, et al.
Nat Genet
. 2018 Apr;
50(4):498-503.
PMID: 29610478
β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia result from mutations in the adult HBB (β-globin) gene. Reactivating the developmentally silenced fetal HBG1 and HBG2 (γ-globin) genes is a...
15.
Norton L, Funnell A, Burdach J, Wienert B, Kurita R, Nakamura Y, et al.
Blood Adv
. 2018 Jan;
1(11):685-692.
PMID: 29296711
Genes encoding the human β-like hemoglobin proteins undergo a developmental switch from fetal to adult expression around the time of birth. β-hemoglobinopathies, such as sickle-cell disease and β-thalassemia, result from...
16.
Hamey J, Wienert B, Quinlan K, Wilkins M
Mol Cell Proteomics
. 2017 Jul;
16(12):2229-2242.
PMID: 28663172
Lysine methylation is widespread on human proteins, however the enzymes that catalyze its addition remain largely unknown. This limits our capacity to study the function and regulation of this modification....
17.
Wienert B, Martyn G, Kurita R, Nakamura Y, Quinlan K, Crossley M
Blood
. 2017 Jun;
130(6):803-807.
PMID: 28659276
β-Hemoglobinopathies are among the most common single-locus inherited diseases. In this condition, high fetal hemoglobin (HbF) levels have been found to be beneficial, and boosting HbF expression is seen as...
18.
Wienert B, Funnell A, Norton L, Pearson R, Wilkinson-White L, Lester K, et al.
Nat Commun
. 2015 May;
6:7085.
PMID: 25971621
Genetic disorders resulting from defects in the adult globin genes are among the most common inherited diseases. Symptoms worsen from birth as fetal γ-globin expression is silenced. Genome editing could...
19.
Dewi V, Kwok A, Lee S, Lee M, Tan Y, Nicholas H, et al.
J Biol Chem
. 2015 Feb;
290(13):8591-605.
PMID: 25659434
Krüppel-like factor 3 (KLF3/BKLF), a member of the Krüppel-like factor (KLF) family of transcription factors, is a widely expressed transcriptional repressor with diverse biological roles. Although there is considerable understanding...
20.
Funnell A, Vernimmen D, Lim W, Mak K, Wienert B, Martyn G, et al.
BMC Mol Biol
. 2014 Jun;
15:8.
PMID: 24885809
Background: Krüppel-like Factor 3 (KLF3) is a broadly expressed zinc-finger transcriptional repressor with diverse biological roles. During erythropoiesis, KLF3 acts as a feedback repressor of a set of genes that...