Be Wieringa
Overview
Explore the profile of Be Wieringa including associated specialties, affiliations and a list of published articles.
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76
Citations
2333
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Recent Articles
1.
Xicoy H, Brouwers J, Wieringa B, Martens G
Cells
. 2020 Aug;
9(9).
PMID: 32858884
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons from the substantia nigra (SN) that project to the dorsal striatum (caudate-putamen). To better understand the molecular mechanisms underlying...
2.
Andre L, van Cruchten R, Willemse M, Bezstarosti K, Demmers J, van Agtmaal E, et al.
Int J Mol Sci
. 2019 Nov;
20(22).
PMID: 31766224
The congenital form of myotonic dystrophy type 1 (cDM) is caused by the large-scale expansion of a (CTG•CAG) repeat in and . The production of toxic transcripts with long trinucleotide...
3.
Xicoy H, Brouwers J, Kalnytska O, Wieringa B, Martens G
Mol Neurobiol
. 2019 Sep;
57(2):848-859.
PMID: 31493240
Parkinson's disease (PD) is a highly prevalent neurodegenerative disease for which no disease-modifying treatments are available, mainly because knowledge about its pathogenic mechanism is still incomplete. Recently, a key role...
4.
Hendriks W, Bakker N, Pluk H, de Brouwer A, Wieringa B, Cambi A, et al.
BMC Med Educ
. 2019 Jun;
19(1):178.
PMID: 31151456
Background: Study motivation and knowledge retention benefit from regular student self-assessments. Inclusion of certainty-based learning (CBL) in computer-assisted formative tests may further enhance this by enabling students to identify whether...
5.
van Cruchten R, Wieringa B, Wansink D
RNA
. 2019 Feb;
25(4):481-495.
PMID: 30700578
Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disorder caused by expansion of a CTG repeat in the 3'-untranslated region (UTR) of the gene. Mutant transcripts form aberrant structures...
6.
Xicoy H, Wieringa B, Martens G
Cells
. 2019 Jan;
8(1).
PMID: 30621069
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and microgliosis. During the past decades multiple...
7.
Andre L, Ausems C, Wansink D, Wieringa B
Front Neurol
. 2018 Jun;
9:368.
PMID: 29892259
Myotonic dystrophy type 1 (DM1) and 2 (DM2) are autosomal dominant degenerative neuromuscular disorders characterized by progressive skeletal muscle weakness, atrophy, and myotonia with progeroid features. Although both DM1 and...
8.
Gudde A, van Kessel I, Andre L, Wieringa B, Wansink D
Biochim Biophys Acta Gene Regul Mech
. 2017 Apr;
1860(6):740-749.
PMID: 28435090
In yeast and higher eukaryotes nuclear retention of transcripts may serve in control over RNA decay, nucleocytoplasmic transport and premature cytoplasmic appearance of mRNAs. Hyperadenylation of RNA is known to...
9.
Gonzalez-Barriga A, Nillessen B, Kranzen J, van Kessel I, Croes H, Aguilera B, et al.
Nucleic Acid Ther
. 2017 Apr;
27(3):144-158.
PMID: 28375678
Clinical efficacy of antisense oligonucleotides (AONs) for the treatment of neuromuscular disorders depends on efficient cellular uptake and proper intracellular routing to the target. Selection of AONs with highest in...
10.
van Agtmaal E, Andre L, Willemse M, Cumming S, van Kessel I, van den Broek W, et al.
Mol Ther
. 2017 Jan;
25(1):24-43.
PMID: 28129118
Myotonic dystrophy type 1 (DM1) is caused by (CTG⋅CAG)-repeat expansion within the DMPK gene and thought to be mediated by a toxic RNA gain of function. Current attempts to develop...